An Analysis of The Trend of Incidences and Fatality of Pulmonary Tuberculosis in East Java from 2015-2020: A Lesson From COVID-19

Authors

  • Muhamad Frendy Setyawan Universitas Airlangga, Surabaya, Indonesia
  • Ni Made Mertaniasih Universitas Airlangga, Surabaya, Indonesia
  • Budi Utomo Universitas Airlangga, Surabaya, Indonesia
  • Soedarsono Soedarsono Hang Tuah University, Surabaya, Indonesia
  • I Made Dwi Mertha Adnyana Universitas Airlangga, Surabaya, Indonesia
  • Dwinka Syafira Eljatin Universitas Airlangga, Surabaya, Indonesia
  • Lesty Helda Marsel Sumah Airlangga University, Surabaya, Indonesia
  • Citra Al Karina Airlangga University, Surabaya, Indonesia
  • Zakiyathun Nuha Airlangga University, Surabaya, Indonesia

DOI:

https://doi.org/10.55489/njcm.140520232903

Keywords:

COVID-19, pulmonary tuberculosis, prevalence, surveillance, correlation

Abstract

Background: Pulmonary tuberculosis is still a public health problem, and surveillance data analysis has not been done much. Recently a global pandemic of COVID-19 has the potential in disturbing TB elimination programs and treatment. This study aims to comprehensively analyse the incidence rate (IR) and Case Fatality Rate (CFR) of pulmonary tuberculosis in East Java from 2015–2020 and during COVID-19 and the strategies for optimizing tuberculosis disease control.

Methodology: The study analyzed annual surveillance data using an analytical descriptive design. The Variables were analyzed with Spearman correlation with a level of evidence of 95% (p<0.05).

Results: The prevalence of pulmonary tuberculosis in East Java fluctuated from 2015–2020. In 2020 and during the COVID-19 pandemic, the number of cases and morbidity rates increased. Statistic results confirm the presence of a significant correlation between the values of Incidence rate (IR) and Case Fatality rate (CFR) (p = 0.032), IR and Treatment Success Rate (TSR) (p = 0.020), and CFR and TSR (p = 0.002). Population density is not correlated with the number of new cases (p = 0.667). Treatment rates have increased to 51%; cure and treatment rates have decreased to 76% and 89%, respectively, and there was a 4% increase in mortality during COVID-19.

Conclusions: COVID-19 has tremendously affected the treatment of pulmonary TB cases in East Java, Indonesia by increasing the incidence rate and decreasing the fatality rate. The pandemic promotes fear in the community to check their medical status and improve the quality of their health in East Java.

References

Utomo B, Chan CK, Mertaniasih NM, Soedarsono S, Fauziyah S, Sucipto TH, et al. Comparison Epidemiology between Tuberculosis and COVID-19 in East Java Province, Indonesia: An Analysis of Regional Surveillance Data in 2020. Trop Med Infect Dis. 2022 May 27;7(6):83. Doi: https://doi.org/10.3390/tropicalmed7060083 PMid:35736962 PMCid:PMC9230370

Ministry of Health Republic of Indonesia. The Republic of Indonesia Joint External Monitoring Mission for Tuberculosis [Internet]. 2021. p. 105. Available from: https://tbindonesia.or.id/wp-content/uploads/2021/06/INDONESIA-JEMM-2020-Eng-1.pdf

WHO. Global tuberculosis report 2021 [Internet]. Geneva; 2021. Available from: https://www.who.int/publications/i/item/9789240037021

Winardi W, Wahyuni H, Hidayat M, Wirawan A, Uddin MN, Yusup M. Challenges on tuberculosis care in health care facilities during COVID-19 pandemic: Indonesian perspective. Narra J [Internet]. 2022 Aug 1;2(2):e80. Doi: https://doi.org/10.52225/narra.v2i2.80

Togun T, Kampmann B, Stoker NG, Lipman M. Anticipating the impact of the COVID-19 pandemic on TB patients and TB control programmes. Ann Clin Microbiol Antimicrob. 2020;19(1):1-6. Doi: https://doi.org/10.1186/s12941-020-00363-1 PMid:32446305 PMCid:PMC7245173

Visca D, Ong CWM, Tiberi S, Centis R, D'Ambrosio L, Chen B, et al. Tuberculosis and COVID-19 interaction: A review of biological, clinical and public health effects. Pulmonology [Internet]. 2021;27(2):151-65. Doi: https://doi.org/10.1016/j.pulmoe.2020.12.012 PMid:33547029 PMCid:PMC7825946

Caren GJ, Iskandar D, Pitaloka DA, Abdulah R, Suwantika AA. COVID-19 Pandemic Disruption on the Management of Tuberculosis Treatment in Indonesia. J Multidiscip Healthc. 2022 Jan;Volume 15:175-83. Doi: https://doi.org/10.2147/JMDH.S341130 PMid:35115781 PMCid:PMC8801372

Pontali E, Sotgiu G, D'Ambrosio L, Centis R, Migliori GB. Bedaquiline and multidrug-resistant tuberculosis: A systematic and critical analysis of the evidence. European Respiratory Journal [Internet]. 2016;47(2):394-402. Doi: https://doi.org/10.1183/13993003.01891-2015 PMid:26828052

The TB/COVID-19 Global Study Group. Tuberculosis and COVID-19 co-infection: description of the global cohort. European Res-piratory Journal [Internet]. 2022 Mar;59(3):2102538. Doi: https://doi.org/10.1183/13993003.02538-2021 PMid:34764184 PMCid:PMC8588566

Nath R, Gupta NK, Gupta N, Tiwari P, Kishore J, Ish P. Effect of COVID-19 pandemic on tuberculosis notification. Indian Journal of Tuberculosis. 2022 Jul;69(3):364-5. Doi: https://doi.org/10.1016/j.ijtb.2021.08.007 PMid:35760488 PMCid:PMC8358081

Kwak N, Hwang SS, Yim JJ. Effect of COVID-19 on Tuberculosis Notification, South Korea. Emerg Infect Dis. 2020 Oct;26(10):2506-8. Doi: https://doi.org/10.3201/eid2610.202782 PMid:32672531 PMCid:PMC7510739

Arentz M, Ma J, Zheng P, Vos T, Murray CJL, Kyu HH. The impact of the COVID-19 pandemic and associated suppression measures on the burden of tuberculosis in India. BMC Infect Dis. 2022;22(1):1-8. Doi: https://doi.org/10.1186/s12879-022-07078-y PMid:35086472 PMCid:PMC8792515

Dowdy DW. Has the COVID-19 pandemic increased tuberculosis mortality? Lancet Infect Dis. 2022;22(2):165-6. Doi: https://doi.org/10.1016/S1473-3099(22)00006-8 PMid:35092788

Darwin M, Mamondol MR, Sormin SA, Nurhayati Y, Tambunan H, Sylvia D, et al. Quantitative approach research method. 1st ed. Tambunan TS, editor. Bandung: CV Media Sains Indonesia; 2021. 192 p.

Mertha Adnyana IMD. Prinsip Epidemiologi. In: Asir AI, editor. Epidemiologi Penyakit Menular [Internet]. 1st ed. Bandung: CV Media Sains Indonesia; 2022. p. 19-40. Available from: https://books.google.co.id/books?id=zwaMEAAAQBAJ

Public Health Office East Java. East Java Provincial Health Office 2020 [Internet]. East Java; 2021. Available from: https://dinkes.jatimprov.go.id/

Public Health Office East Java. East Java Provincial Health Office 2018 [Internet]. East Java; 2019. Available from: https://dinkes.jatimprov.go.id/

Public Health Office East Java. East Java Provincial Health Office 2019 [Internet]. East Java; 2020. Available from: https://dinkes.jatimprov.go.id/

Public Health Office East Java. East Java Provincial Health Office 2016 [Internet]. East Java; 2017. Available from: https://dinkes.jatimprov.go.id/

Public Health Office East Java. East Java Provincial Health Office 2017 [Internet]. East Java; 2018. Available from: https://dinkes.jatimprov.go.id/

Public Health Office East Java. East Java Provincial Health Office 2015 [Internet]. East Java; 2016. Available from: https://dinkes.jatimprov.go.id/

Agustiawan, Adnyana IMDM, Ashriady, Paramata Y, Asrianti T, Silalahi LE, et al. Epidemiologi Penyakit Menular. 1st ed. Asir AI, edi-tor. Bandung: CV Media Sains Indonesia; 2022. 236 p.

Abdullahi OA, Ngari MM, Sanga D, Katana G, Willetts A. Mortality during treatment for tuberculosis; a review of surveillance data in a rural county in Kenya. PLoS One. 2019;14(7):1-15. Doi: https://doi.org/10.1371/journal.pone.0219191 PMid:31295277 PMCid:PMC6622488

Koupaei M, Naimi A, Moafi N, Mohammadi P, Tabatabaei FS, Ghazizadeh S, et al. Clinical Characteristics, Diagnosis, Treatment, and Mortality Rate of TB/COVID-19 Coinfectetd Patients: A Systematic Review. Front Med (Lausanne). 2021 Dec 1;8:740593. Doi: https://doi.org/10.3389/fmed.2021.740593 PMid:34926494 PMCid:PMC8671757

Fadaak R, Davies JM, Blaak MJ, Conly J, Haslock J, Kenny A, et al. Rapid conversion of an in-patient hospital unit to accommodate COVID-19: An interdisciplinary human factors, ethnography, and infection prevention and control approach. PLoS One [Internet]. 2021;16(1 January):1-17. Doi: https://doi.org/10.1371/journal.pone.0245212 PMid:33481807 PMCid:PMC7822252

Lewer D, Mulchandani R, Roche A, Cosgrove C, Anderson C. Why has the incidence of tuberculosis not reduced in London during the COVID-19 pandemic? Lancet Respir Med. 2022;10(3):231-3. Doi: https://doi.org/10.1016/S2213-2600(22)00012-1 PMid:35032431

Stojanovic Z, Prat-Aymerich C, Aymerich CP. Impact of COVID-19 on tuberculosis: Turning challenges into opportunities. Revista Enfermedades Emergentes [Internet]. 2021;20(3):151-4. Available from: http://enfermedadesemergentes.com/articulos/a788/0 editorial 3_2021_web.pdf

al Mayahi Z, Alaufi I, al Ghufaili B, al Balushi Z, al Mughazwi Z, Mohammed E, et al. Epidemiological profile and surveillance activity of tuberculosis in South Batinah, Oman, 2017 and 2018. Int J Mycobacteriol. 2020 Jan 1;9(1):39-47.

Rahimi BA, Rahimy N, Mukaka M, Ahmadi Q, Hayat MS, Wasiq AW. Determinants of treatment failure among tuberculosis patients in Kandahar City, Afghanistan: A 5-year retrospective cohort study. Int J Mycobacteriol. 2019 Oct 1;8(4):359-65. Doi: https://doi.org/10.4103/ijmy.ijmy_142_19 PMid:31793506

McQuaid CF, Vassall A, Cohen T, Fiekert K, White RG. The impact of COVID-19 on TB: A review of the data. International Journal of Tuberculosis and Lung Disease. 2021;25(6):436-46. Doi: https://doi.org/10.5588/ijtld.21.0148 PMid:34049605 PMCid:PMC8171247

Wang X, He W, Lei J, Liu G, Huang F, Zhao Y. Impact of COVID-19 Pandemic on Pre-Treatment Delays, Detection, and Clinical Charac-teristics of Tuberculosis Patients in Ningxia Hui Autonomous Region, China. Front Public Health. 2021;9(May):1-8. Doi: https://doi.org/10.3389/fpubh.2021.644536 PMid:34095053 PMCid:PMC8175850

WHO. Global tuberculosis report 2021 [Internet]. 2021st ed. Global Tuberculosis Programme, editor. WHO report; 2021. 57 p. Available from: https://www.who.int/publications/i/item/9789240037021

Yadav P, Vohra C, Gopalakrishnan M, Garg MK. Integrating health planning and primary care infrastructure for COVID‐19 and tuber-culosis care in India: Challenges and opportunities. Int J Health Plann Manage. 2022 Mar 24;37(2):632-42. Doi: https://doi.org/10.1002/hpm.3393 PMid:34820907 PMCid:PMC9015569

Tiberi S, Vjecha MJ, Zumla A, Galvin J, Migliori GB, Zumla A. Accelerating development of new shorter TB treatment regimens in an-ticipation of a resurgence of multi-drug resistant TB due to the COVID-19 pandemic. International Journal of Infectious Diseases. 2021 Dec;113:S96-9. Doi: https://doi.org/10.1016/j.ijid.2021.02.067 PMid:33713815 PMCid:PMC7944856

Gupta N, Bhatnagar T, Rade K, Murhekar M, Gangakhedkar R, Nagar A, et al. Strategic planning to augment the testing capacity for COVID-19 in India. Indian Journal of Medical Research. 2020;151(2):210. Doi: https://doi.org/10.4103/ijmr.IJMR_1166_20 PMid:32362646 PMCid:PMC7366548

Geric C, Saroufim M, Landsman D, Richard J, Benedetti A, Batt J, et al. Impact of COVID-19 on Tuberculosis Prevention and Treatment in Canada: A Multicenter Analysis of 10 833 Patients. Journal of Infectious Diseases. 2022;225(8):1317-20. Doi: https://doi.org/10.1093/infdis/jiab608 PMid:34919700 PMCid:PMC8755327

Ruhwald M, Hannay E, Sarin S, Kao K, Sen R, Chadha S. Considerations for simultaneous testing of COVID-19 and tuberculosis in high-burden countries. Lancet Glob Health. 2022 Apr;10(4):e465-6. Doi: https://doi.org/10.1016/S2214-109X(22)00002-X PMid:35122718

Baker MG, Wilson N, Blakely T. Elimination could be the optimal response strategy for covid-19 and other emerging pandemic dis-eases. BMJ. 2020 Dec 22;371:m4907. Doi: https://doi.org/10.1136/bmj.m4907 PMid:33561814

Ehrenberg JP, Zhou XN, Fontes G, Rocha EMM, Tanner M, Utzinger J. Strategies supporting the prevention and control of neglected tropical diseases during and beyond the COVID-19 pandemic. Infect Dis Poverty. 2020 Dec 10;9(1):86. Doi: https://doi.org/10.1186/s40249-020-00701-7 PMid:32646512 PMCid:PMC7347419

Wingfield T, Karmadwala F, MacPherson P, Millington KA, Walker NF, Cuevas LE, et al. Challenges and opportunities to end tubercu-losis in the COVID-19 era. Vol. 9, The Lancet Respiratory Medicine. 2021. p. 556-8. Doi: https://doi.org/10.1016/S2213-2600(21)00161-2 PMid:33773121

Ruhwald M, Hannay E, Sarin S, Kao K, Sen R, Chadha S. Considerations for simultaneous testing of COVID-19 and tuberculosis in high-burden countries. Lancet Glob Health. 2022 Apr;10(4):e465-6. Doi: https://doi.org/10.1016/S2214-109X(22)00002-X PMid:35122718

Saini V, Garg K. Case finding strategies under National Tuberculosis Elimination Programme (NTEP). Indian Journal of Tuberculosis. 2020 Dec;67(4):S101-6. Doi: https://doi.org/10.1016/j.ijtb.2020.09.029 PMid:33308653 PMCid:PMC7526527

Liao J, Minicucci C, National Academies of Sciences and Medicine E. Innovations for Tackling Tuberculosis in the Time of COVID-19 [Internet]. Biffl C, Liao J, Nicholson A, editors. Washington, D.C.: National Academies Press; 2022. Available from: https://www.nap.edu/catalog/26530

Reid MJA, Silva S, Arinaminpathy N, Goosby E. Building a tuberculosis-free world while responding to the COVID-19 pandemic. The Lancet. 2020 Oct;396(10259):1312-3. Doi: https://doi.org/10.1016/S0140-6736(20)32138-3 PMid:34338198

Vázquez-Temprano N, Ursúa-Díaz MI, Salgado-Barreira Á, Vázquez-Gallardo R, Túñez Bastida V, Anibarro L. Decline of Tuberculosis Rates and COVID-19 Pandemic. Fact or Fiction? Arch Bronconeumol. 2021;58:272-4. Doi: https://doi.org/10.1016/j.arbres.2021.05.035 PMid:34092895 PMCid:PMC8836678

Song WM, Zhao JY, Zhang QY, Liu SQ, Zhu XH, An QQ, et al. COVID-19 and Tuberculosis Coinfection: An Overview of Case Re-ports/Case Series and Meta-Analysis. Front Med (Lausanne). 2021;8(August):1-13. Doi: https://doi.org/10.3389/fmed.2021.657006 PMid:34504847 PMCid:PMC8421570

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Published

2023-05-01

How to Cite

1.
Setyawan MF, Mertaniasih NM, Utomo B, Soedarsono S, Adnyana IMDM, Eljatin DS, Sumah LHM, Al Karina C, Nuha Z. An Analysis of The Trend of Incidences and Fatality of Pulmonary Tuberculosis in East Java from 2015-2020: A Lesson From COVID-19. Natl J Community Med [Internet]. 2023 May 1 [cited 2024 Dec. 22];14(05):308-15. Available from: https://njcmindia.com/index.php/file/article/view/2903

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Original Research Articles