Extra-pulmonary Symptoms in HIV Positive Patient and It’s Correlation with CD4 Count


  • Vandana Dhangar SMIMER, Surat
  • Ashok Gagiya SMIMER, Surat
  • Kamal Naik SMIMER, Surat
  • Sailendra Gamit SMIMER, Surat


HIV, CD4 count, Extra pulmonary, Tuberculosis, Mortality


Background: There is correlation between HIV& pulmonary TB. Patient with HIV has higher incidence of pulmonary TB. It is also noted the correlation of CD4 count with TB manifestations i.e. Pulmonary & extra-pulmonary TB.

Methods: Observational study in 70 patients with HIV in SMIMER, SURAT. Investigations were done with all routine with specific CD4 count. The rate analysed according to CD4 count.

Results: In HIV patients TB is common. There are two groups, Pulmonary and extra-pulmonary. After analysis of data, it is noted that there is a significant correlation with CD4 count. Pulmonary TB cases were common with CD4 count 300-500 and extra-pulmonary TB cases were common with CD4 < 300. Lymph-node TB (200-300), TB meningitis (100-200), Disseminated TB (<100) were also common in lower CD4 count.

Conclusion: CD4 count is very important to determine type of tuberculosis in HIV positive patients. Also it is very important to determine morbidity& mortality.


JR Shankaran. CD4 + Lymphocytes and HIV disease. J As-soc Physicians India. 1997; 145(9): 718-721.

Kumar P, Sharma N, Sharma NC, Patnaik S. Clinical pro-file of tuberculosis in patients with HIV infection / AIDS. Indian J Chest Dis Allied Sci 2002; 44 : 159-163.

Gonzalez OY, Adams G, Teeter LD, Bui TT, Musser JM, Graviss EA. Extra-pulmonary manifestation in a large met-ropolitan area with a low incidence of tuberculosis. Int J Tuberc Lung Dis 2003;7:1178-85.

MS Zaheer, MV Rabbani, Zuber Ahmed, Tamkinkhan BB Rewari, DK Pandey: Clinical and demographic profile of patients of Acquired Immunodeficiency Syndrome in and around Aligarh. J Ind Academy of Clinical Med 2003; 4(2): 121-126

SK Sharma, Aggarwal G, Seth P, Saha PK. Increasing HIV seropositivity among adult tuberculosis patients in delhi. Ind J Med Res. 2003, 117:239-242

Kumara swamy N. Changing trends of opportunistic infec-tions among HIV diseases persons in Chennai, India. Wrap-up YRG Health letter 1997.

Global Aids Response Progress Reporting 2014. Available on http://www.unaids.org/sites/default/files/media_a sset/GARPR_2014_guidelines_en_0.pdf. Accessed on Jan 12, 2018

Jaryal A, Raina R, Sarkar M, Sharma A. Manifestations of tuberculosis in HIV/AIDS patients and its relationship with CD4 count. Lung India 2011;28:263-6

Gupta RK, Lawn SD, Bekker LG, Caldwell J, Kaplan R, Wood R. Impact of HIV and CD4 count on tuberculosis di-agnosis: analysis of citywide data from Cape Town, South Africa. Int J Tuberc Lung Dis. 2013 Aug; 17(8): 1014–1022.

Chakravarty J, Mehta H, Parekh A, Attili SV, Agrawal NR, Singh SP, Sundar S. Study on clinic-epidemiological pro-file of HIV patients in eastern India. J Assoc Physicians In-dia. 2006;54:854-7.

K. Kothari, S. Goyal. Clinical profile of Acquired Immu-nodeficiency Syndrome. J Assoc Physicians India. 2001; 49: 435-8.

R. Ananthnarayan, LK Jayaram Paniker. Human Immuno-deficiency Virus: Acquired Immunodeficiency Syndrome. Textbook of Microbiology, 7th edition. Universities Press, Hyderabad, India, 2009: 582-598.

National AIDS Control Organization, Ministry of health & family Welfare, Government of India. HIV/ AIDS surveil-lance in India. Available from http://nacoonline.org /facts_overview.htm. Accessed on Jan 12, 2018.




How to Cite

Dhangar V, Gagiya A, Naik K, Gamit S. Extra-pulmonary Symptoms in HIV Positive Patient and It’s Correlation with CD4 Count. Natl J Community Med [Internet]. 2017 Nov. 30 [cited 2024 Jul. 21];8(11):702-4. Available from: https://njcmindia.com/index.php/file/article/view/1653



Original Research Articles