Prevalence of Non Alcoholic Fatty Liver Disease (NAFLD) among Adults Aged 30 Years and Above in a Rural Population of Jammu- An Observational Study
Keywords:
Nonalcoholic fatty liver disease (NAFLD), Prevalence, Risk factors, Rural areaAbstract
Background: Non alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease globally and its burden is increasing in India. There is still paucity of knowledge regarding the actual burden and risk factors of NAFLD especially in rural areas.
Methodology: The present study was conducted in six villages under Health and Demographic Surveillance System (HDSS) in Block RS Pura. A total of 322 adults aged 30 years and above were selected using simple random sampling to estimate the prevalence of NAFLD . The number of eligible participants as per inclusion criteria were 258 and Out of them, finally 250 participants reported for undergoing ultrasonography of the liver, anthropometry, blood pressure recording, and biochemical tests .
Results: Prevalence of NAFLD was 37.2% (31.4-43.3). Majority of participants had mild severity (57%). Persons with low physical activity and high BMI (both overweight and obese persons) had maximum prevalence of NAFLD 66.7%, 26.2% and 43.07% respec- tively. Hypertensives and women with higher waist hip ratio also reported higher prevalence. Regarding biochemical levels, the prevalence was higher in subjects having high SGOT (69.8%), SGPT (43.5%), serum alkaline phosphates (43.4%) and serum LDL levels(64.4%).
Conclusions: The prevalence of NAFLD is high in rural areas of India.
References
Clark JM, Brancati FL, Diehl AM. The prevalence and etiol- ogy of elevated aminotransferase levels in the united states. AMJ Gastroenterology 2003; 98: 960-7.
Kalra S, Vithalani M, Gulati G, Kulkarni CM, Kadam Y, Pallivathukkal J et al. Study of prevalence of non-alcoholic fatty liver disease(NAFLD) in type 2 diabetes patients in In- dia (SPRINT). J Assoc Physicians India .2013; (7):448-53.
Amarapurkar D, Kamani P, Patel N, Gupte P, Kumar P, Agal S et al. Prevalence of Non-alcoholic fatty liver disease: population based study. Ann Hepatol.2007; 6(3):161-3.
Mohan V, Farooq S, Deepa M, Ravikumar R, Pitchumoni CS. Prevalence of non-alcoholic fatty liver disease in urban south Indians in relations to different grades of glucose in- tolerance and metabolic syndrome. Diabetes research and clinical practice.2009; 84(1):84-91. 5.Marchesini G, Bugianesi E, Forlani G, Cerrelli F, Lenzi M, Manini R, et al. Non alco- holic fatty liver, steatohepatitis and the metabolic syn- drome. Hepatology 2003;37(4):917-23.
Ali R, Cust k. New diagnostic and treatment approaches in non-alcoholic fatty liver disease (NAFLD). Ann Med 2009; 41:265-78.
Ratziu V, Giral P, Charlotte F, Bruckert E, Thibault V, Theodorou I, et al. Liver fibrosis in overweight patients. Gastroenterolgy 2000; 118(6):1117-23.
WHO Technical Report Series(WTRS). Physical status: the use and interpretation of anthropometry. WHO Technical Report series 995;854:427-33. www.who.int/childgrowth/ publications/physical_ status/en/(accessed on 02 Sep 2018)
Das K, Mukherjee PS, Ghosh A, Ghosh S, Mridha AR, Dhibar T et al. Nonobese population in a developing coun- try has a high prevalence of nonalcoholic fatty liver and sig- nificant liver disease. Hepatology.2010; 51(5):1593-602.
Majumdar A, Misra P, Sharma S, Kant S, Krishnan A, Pandav C S. Prevalence of Nonalcoholic Fatty Liver Disease in an Adult Population in a Rural Community of Haryana, India. .Indian J Public Health.2016; 60(1):26-33.
Amirkalali B, Poustchi H, Keyvani H, Khansari MR, Ajdarkosh H, Maadi et al. Prevalence of Non-Alcoholic Fat- ty Liver Disease and its Predictors in North of Iran. Iranian J Public Health 2014; 43(9):1275-83.
Angulo P. Nonalcoholic fatty liver disease. New England Journal of Medicine. 2002 18;346(16):1221-31.
Sharda M Yagnik D, Soni A, Nigam H. Non-Alcoholic Fatty Liver Disease (NAFLD) and its association with metabolic syndrome and cardiovascular disease. International Multi- speciality Journal of Health.2015;1(8).
Rao V S, Sikariya K K. Prevalence and Risk Factors of Non- alcoholic Fatty Liver Disease in Type 2 Diabetes Mellitus in a Tertiary Care Centre In Western India. IOSR Journal of Dental and Medical Sciences. 2016;15(2):01-07.
Bedogni G, Miglioli L, Masutti F, Tiribelli C, Mar-chesini G, Bellentani S Prevalence of and risk factors for nonalcoholic fatty liver disease: the Dionysos nutrition and liver study. Hepatology. 2005; 42 (1): 44-52.
Singh SP, Nayak S, Swain M, Rout N, Mallik RN, Agrawal O et al. Prevalence of Nonalcoholic fatty liver diseases in coastal eastern India a preliminary ultrasonographic survey. Trop Gastroenterol 2004; 25(2):76-9.
Bajaj S, Nigam P, Luthra A, PandeyRM, Kondal D, Bhatt SP. A case control study on insulin resistance, metabolic co- variates & predicition score in non-alcoholic fatty liver dis- ease. Indian J Med Res.2009;129(3):285-92.
Dassanayake AS, Kasturiratne A, Rajindrajith S,Kalubowila U,Chakrawarthi S, De Silva AP et al. Prevalence and risk factors for non-alcoholic fatty liver disease among adults in an urban Srilankan population.J Gastroenterol Hepatol. 2009;24(7):1284-8.
Chen CH, Huang MH, Yang JC, Nien CK, Yang CC, Yeh YH, et al. Prevalence and risk factors of nonalcoholic fatty liver disease in an adult population of Taiwan: metabolic significance of nonalcoholic fatty liver disease in nonobese adults. J ClinGastroenterol.2006; 40 (8): 745-52.
Hamabe A, Uto H, Imamura Y, Kusano K, Mawatari S, Kumagai K et al. Impact of cigarette smoking on onset of nonalcoholic fatty liver disease over a 10-year period. Jour- nal of Gastroenterology.2011; 46(6):769-778.
Sung KC, Kim BS, Cho YK, Park DI, Woo S, Kim S et al. Predicting incident fatty liver using simple cardio-metabolic risk factors at baseline. BMC Gastroenterology.2012; 12:84.
Xu C, Yu C, Ma H, Xu L, Miao M, Li Y. Prevalence and risk factors for the development of non alcoholic fatty liver dis- ease in a non obese Chinese population: the Zhejiang Zhenhai Study.
Arulanandan A, Ang B, Bettencourt R, et al. Association between quantity of liver fat and cardiovascular risk in patients with nonalcoholic fatty liverdisease independent of nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2015.
Gerber L, Otgonsuren M, Mishra A, et al. Non-alcoholic fat- ty liver disease (NAFLD) is associated with low level of physical activity: a population-based study. Aliment Pharmacol Ther 2012;36:772–78.
Singh SP, Nayak S, Swain M, Rout N, Mallik RN, Agrawal O, et al. Prevalence of non-alcoholic fatty liver disease in coastal eastern India: A preliminary ultrasonographic sur- vey. Trop Gastroenterol 2004;25:76-9.
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