A Study of Adverse Effects Following Administration of Anti-Rabies Vaccination - A Hospital Based Study


  • Manasi Panda Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India
  • Richa Kapoor Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India




Rabies, Anti-rabies vaccine, Adverse effect following immunisation, Post-exposure prophylaxis


Rabies is an acute viral zoonotic disease that affects all warm-blooded animals including mammals and occurs in more than 150 countries and territories. Although rabies is a 100% fatal disease, it can be prevented by the use of potent anti-rabies vaccines (ARV). The present study was a hospital based descriptive longitudinal study conducted during February 2019 to July 2020 amongst the animal bite patients attending the Anti -Rabies clinic (ARC) of Vardhman Mahavir Medical College and Safdarjung Hospital (VMMC & SJH), New Delhi, to study the adverse events (vaccine reactions) if any following administration of the ARV. The age of the study participants ranged from 2 to 65 years and the mean age was (29.3±15.2) years. No severe or serious adverse events were reported. Of the minor reactions, the most commonly reported symptom was pain at the injection site (34; 9.4%) followed by occurrence of tingling sensation (29; 8.1%), headache (22; 6.1%) and itching at the injection site (19; 5.3%). These findings corroborate with those found in previous studies in the literature. It was concluded that although there are possible local or mild or systemic adverse reactions to rabies vaccination, but once initiated, rabies prophylaxis should not be interrupted or discontinued.


World Health Organization. Rabies Fact Sheet. Available from https://www.who.int/news-room/factsheets/detail/rabies#:~:text=Key%20facts,and%20prevention%20of%20dog%20bites [Last accessed on Jun1, 2020].

World Health Organization. WHO expert consultation on Rabies, 1012. 3rd.2018. Available from https://apps.who.int/iris/bitstream/handle/10665/272364/9789241210218-eng.pdf?ua=1 [Last accessed on Jun1, 2020].

Fooks AR, Banyard AC, Horton DL, Johnson N, McElhinney LM, Jackson AC. Current status of rabies and prospects for elimination. Lancet 2014;384:1389-99. Doi: https://doi.org/10.1016/S0140-6736(13)62707-5

World Health Organization. Background paper - Proposed revision of the policy on rabies vaccines and rabies immunoglobulins. Available from https://www.who.int/immunization/sage/meetings/2017/october/1_Background_paper_WG_RABIES_final.pdf?ua=1 [Last ac-cessed on Jun1,2020].

Sudarshan MK, Madhusudana SN, Mahendra BJ, Rao NS, Aswath Narayana DH, Rahman A et al. Assessing the burden of human rabies in India: results of a national multi-center epidemiological survey. Int J Infect Dis 2007;11:29-35. Doi: https://doi.org/10.1016/j.ijid.2005.10.007 PMid:16678463

Jacob John T. An ethical dilemma in rabies immunization. Vaccine 1997;15:S12-S15. Doi: https://doi.org/10.1016/S0264-410X(96)00316-7

Nishant N, Sankhe L, Rajguru C. Anti Rabies Vaccination compliance: A longitudinal study amongst patients attending Anti Rabies Vaccination OPD in a tertiary care hospital. J Med Sci Clin Res 2018;06:32671-76. Doi: https://doi.org/10.18535/jmscr/v6i1.43

National Centre for Disease Control, DGHS, MOHFW Govt of India. National Rabies Control Program National Guidelines on Rabies Prophylaxis, 2015. Available from http://clinicalestablishments.gov.in/WriteReadData/238.pdf [Last accessed on Jun1, 2020].

WHO Vaccine safety basics: Module 3 - Adverse event following immunization. Available at https://vaccine-safety-training.org/overview-and-outcomes-3.html [Last accessed on Jun1, 2020].

Manning SE, Rupprecht CE, Fishbein D, et al; Advisory Committee on Immunization Practices Centers for Disease Control and Pre-vention (CDC). Human rabies prevention-United States, 2008: recommendations of the Advisory Committee on Immunization Practices. MMWR Recomm Rep. 2008;57(RR-3):1-28.

Shankaraiah RH, Rajashekar RA, Veena V, Hanumanthaiah AD. Compliance to anti-rabies vaccination in post-exposure prophylaxis. Indian J Public Health 2015; 59:58-60. Doi: https://doi.org/10.4103/0019-557X.152867 PMid:25758734

Haradanhalli RS, Anwith HS, Pradeep BS, Isloor S, Bilagumba G. Health-seeking behavior and compliance to post exposure prophy-laxis among animal bite victims in India. Indian J Public Health 2019;63, Suppl S1:20-5

Diallo, M.K., Diallo, A.O., Dicko, A. et al. Human rabies post exposure prophylaxis at the Pasteur Institute of Dakar, Senegal: trends and risk factors. BMC Infect Dis 19, 321 (2019). Doi: https://doi.org/10.1186/s12879-019-3928-0 PMid:30975098 PMCid:PMC6460513

Centers for Disease Control and Prevention (CDC). Rabies: Adverse Reaction. 2011. https://www.cdc.gov/rabies/specific_groups/doctors/adverse_reaction.html .

World Health Organization (WHO). Information Sheet Observed Rate of Vaccine Reactions: Rabies Vaccine. 2012. http://www.who.int/vaccine_safety/initiative/tools/Rabies_Vaccine_rates_information_sheet.pdf.

WHO. Essential medicines and health products: WHO Model Lists of Essential Medicines. 2017b. Access: http://www.who.int/medicines/publications/essentialmedicines/en/. Wikipedia. Rabies vaccine. 2017. Access: https://en.wikipedia.org/wiki/Rabies_vaccine.

Fishbein DB, Yenne KM, Dreesen DW, et al. Risk factors for systemic hypersensitivity reactions after booster vaccinations with hu-man diploid cell rabies vaccine: A nationwide prospective study. Vaccine, 1993, 14:1390- 1394. Doi: https://doi.org/10.1016/0264-410X(93)90167-V

WHO. Rabies vaccines: WHO position paper. Weekly epidemiological record. 2010, No. 32, 85: 309-320. Access: http://www.who.int/wer/2010/wer8532.pdf?ua=1.

World Health Organization (WHO). Frequently asked questions on Rabies. 2013. Access: http://www.who.int/rabies/resources/SEA_CD_278_FAQs_Rabies.pdf.

Government of Canada (GC). Canadian Immunization Guide: Part 4 - Active Vaccines: Rabies Vaccine. 2016. Access: https://www.canada.ca/en/public-health/services/publications/healthy-living/canadian-immunizationguide-part-4-active-vaccines/page-18-rabies-vaccine.html.




How to Cite

Panda M, Kapoor R. A Study of Adverse Effects Following Administration of Anti-Rabies Vaccination - A Hospital Based Study. Natl J Community Med [Internet]. 2022 Jul. 31 [cited 2024 Jun. 23];13(07):487-90. Available from: https://njcmindia.com/index.php/file/article/view/1516



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