Epidemiology of Laboratory Confirmed Measles and Rubella Outbreaks in Rajasthan
Keywords:
Measles, Rubella, Surveillance, EpidemiologyAbstract
Introduction: Measles continues to be a major cause of childhood morbidity and mortality in India. The Measles & Rubella Initiative was launched in 2001 as a global partnership program to strengthen surveillance for measles elimination.
Objective: To determine the proportion of lab confirmed outbreaks by IgM ELISA and to describe the epidemiology of Measles and Rubella outbreak in Rajasthan.
Material and method: this observational study was conducted at WHO Sub National Measles and rubella laboratory at a tertiary centre in Rajasthan. Samples from 112 suspected measles out- breaks from April 2015 to August 2016 were tested for measles and rubella IgM antibodies using WHO approved ELISA kits.
Results: On lab confirmation, only 60% were found to be measles outbreak, 17% were Rubella outbreak and 18% were mixed out- break. 5% outbreaks were neither measles nor Rubella. Most cases were seen in dry months of February and April. Measles cases were found in relatively younger age as compared to Rubella. Most outbreaks were reported from few selected districts.
Conclusion: Though most outbreaks are due to measles, Rubella alone or mixed outbreak are also common in Rajasthan, hence lab diagnosis is key for both Measles and Rubella is essential specially when targeting elimination and justifies inclusion of Rubella vac- cine in National schedule.
References
Moss WJ, Griffin DE. Measles. Lancet 2012; 379:153.
Black FL. Measles. In: Viral infections in humans: Epide- miology and control, Evans AS, Kaslow RA (Eds), Plenum Publishing, New York 1997. p.507.
Keegan R, Dabbagh A, Strebel PM, Cochi SL. Comparing measles with previous eradication programs: enabling and constraining factors. J Infect Dis 2011; 204 Suppl 1:S54.
Bellini WJ, Rota PA. Biological feasibility of measles eradi- cation. Virus Res 2011; 162:72.
Rubella fact sheet; Home page on http://www.who.int/ mediacentre/factsheets/fs367/en/ Reviewed March 2016, cited on 11. Aug 2016)
Measles Fact sheet. Home page on www.who.int/media centre/factsheets/fs286/en/ (reviewed Nov 2016, cited on 10 Dec 2016)
Featherstone D, Brown D, Sanders R. Development of the global measles laboratory network. J Infect Dis 2003;187 Suppl 1 ;S264-9.
Manual for the laboratory diagnosis of measles and rubella virus infection; WHO/IVB/07.01 ORIGINAL: ENGLISH
Centers for Disease Control and Prevention. Recommenda- tions from an ad hoc Meeting of the WHO Measles and Rubella Laboratory Network (LabNet) on use of alterna- tive diagnostic samples for measles and rubella surveil- lance. MMWR Morb Mortal Wkly Rep 2008;57:657-60.
Socioeconomic Factors of Full Immunisation Coverage in India World Journal of Vaccines 2013; 3(3), Article ID:35996,9 pagesDOI:10.4236/wjv.2013.33015
NFHS 4 fact sheet. Available online from http://rchiips. org/NFHS/pdf/NFHS4 /RJ_FactSheet.pdf. last sited on 12.03.17
El Mubarak HS, Van de Bildt MWG, Mustafa OA, Vos HW, Mukhtar MM, Ibrahim SA, Andeweg AC, El Hassan AM, Osterhaus A, De Swart RL: Genetic characterization of wild-type measles viruses circulating in suburban khar- toum, 1997-2000./Gen Virol 2002, 83:1437.
Sunil R Vaidya ,Chandrashekhar G Raut et.al “Laboratory confirmation of rubella infection in suspected measles cas- es”; J Med Virol. 88:1685–1689, 2016. © 2016 Wiley Periodi- cals, Inc.
Syed TanwirAlam, N.K. Hazarika, ArunjyotiSarmah and NayanjyotiSarmah A Retrospective Study of Measles Out- break Investigation in North East India; Int J Curr Microbiol App Sci 2015; 4(8): 399-405 .
Lawrence T, Anish TS, Vijayakumar K, Ramachandran R, Suchithra ET, Rajasi RS. Epidemiology of measles out- breaks in Kerala, India, during 2007–2008. Ann Trop Med Publ Health. 2012;5:89–93
Ramamurty N, Raja D, Gunasekaran P, Varalakshmi E, Mohana S, Jin L: Investigation of measles and rubella out- breaks in Tamil Nadu.
Babita, Sanjeev Suman, Shankar Prakash. “Epidemiological Study of Measles in Bihar”. Journal of Evolution of Medi- cal and Dental Sciences 2013; 2(26): 4695-4700.
Gupta SN, Gupta N, Gupta S. A mixed outbreak of Rubeo- la-rubella in District Kangra of Northern India. J Fam Med Primary Care 2013;2:354-9.
Babita, Sanjeev Suman, Shankar Prakash. “Epidemiological Study of Measles in Bihar”. Journal of Evolution of Medi- cal and Dental Sciences 2013; Vol2, Issue 26, July 1; Page: 4695-4700.
S Bhuniya, D Maji, D Mandal, N Mondal, Measles out- break among the Dukpa tribe of Buxa hills in West Bengal, India: epidemiology and vaccine efficacy Indian Journal of Public Health 2013 57:272-75.
Simbarashechimhuya et al “Trends of rubella incidence during a five year case based surveillance in Zimbabwe” BMC Public health.2015.15:294.
Nicholas C Grassly, Christophe Fraser Seasonal infectious disease epidemiology; Published 7 October 2006.DOI: 10.1098/rspb.2006.3604
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