Risk Factors of Pre-Eclampsia: A Hospital Based Case Control Study
Keywords:
Preeclampsia, risk factors, case control study, PIHAbstract
Introduction: Hypertension, complicating 5 to 7% of all pregnan- cies, is a leading cause of maternal and fetal morbidity, particu- larly due to pre-eclampsia, pre-eclampsia contributes about 8 to 10% of maternal deaths in India.
Methodology: Hospital based case control study; cases were women in post-natal period within 2 days of delivery suffering from pre-eclampsia Controls were Women in post-natal period within 2 days of delivery not suffering from pre-eclampsia of same age (±2 years) as that of cases.
Results: Significant independent risk factors of pre-eclampsia. found were first degree relative with HTN (OR = 5.0; 95% CI 3.2 –
8) ;Twin gestation (OR = 4; 95% CI 1.3 - 12.2) ,Family history of pre-eclampsia (OR = 3.7; 95% CI 1.2 - 11.2), Absence of essential obstetric care (OR = 3; 95% CI 1.8 – 5), History of PIH in previous pregnancy (OR = 2.8; 95% CI 1.5 – 5.0), History of abortion in pre- vious pregnancy (OR = 2.8; 95% CI 1.3 - 5.9), Pre pregnancy BMI (OR = 2.7; 95% CI 5.1 –1.4)
Conclusion: If greater awareness of the associated risk factors leads to earlier diagnosis and improved management, there may be scope for reducing a proportion of the morbidity and mortality from preeclampsia.
References
Dutta D. Text Book of Obstetrics, 6th ed. Kolkata: New cen- tral book agency (P) LTD; 2004. p221
Lindheimer MD, Taler SJ, Cunningham FG. Hypertension in pregnancy. J Am Soc Hypertens [Internet]. American So- ciety of Hypertension; 2008 [cited 2014 Sep 14]; 2 (6):484–94. Available from: http://www.ncbi.nlm.nih.gov/pubmed/ 20409930
Dauda MH. Maternal Ethnicity and Severity of Pre- Eclampsia in Northern Nigeria. 2009; 1 (3):104–7.
N.Gupta. Maternal Mortality: Magnitude causes and Con- cerns. Obs Gynecol. 2004; 555–9.
Ganesh KS, Unnikrishnan B, Nagaraj K, Jayaram S. Deter- minants of Pre-eclampsia: A Case-control Study in a District Hospital in South India. Indian J Community Med [Inter- net]. 2010 Oct [cited 2014 Oct 19]; 35 (4):502–5.
Jafary SN. Prevention of Pre-Eclampsia - Is It Possible ? 8– 10.
Cohen, S., Kamarck, T., & Mermelstein R. “A Global Meas- ure of Perceived Stress Scale.”J Health Soc Behav. 1983; 24: 385–96.
Kashanian M, Baradaran HR, Bahasadri S, Alimohammadi
R. Risk factors for pre-eclampsia: a study in Tehran, Iran. Arch Iran Med [Internet]. 2011 Nov [cited 2014 Nov 27]; 14 (6):412–5. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/22039846
Shamsi U, Hatcher J, Shamsi A, Zuberi N, Qadri Z, Saleem
S. A multicentre matched case control study of risk factors for Preeclampsia in healthy women in Pakistan. 2010;
.manandhar BL, Chongstuvivatwong V, Geater A. Antenat- al Care and Severe Pre-Eclampsia in Kathmandu Valley. J Chitwan Med Coll [Internet]. 2014 Jan 11 [cited 2014 Nov 24]; 3 (4):43–7. Available from http://www.nepjol.info/index.php/JCMC/article/view/955
Agrawal AS, Walia GK. Prevalence and risk factors for Pre- eclampsia in Indian women : a national cross sectional study Prevalence and risk factors for Pre-eclampsia in In- dian women : a national cross sectional study. : 1–23.
Wandabwa J, Doyle P, Kiondo P, Campbell O, Maconichie N, Welishe G. Risk factors for severe pre - eclampsia and ec- lampsia in mulago hospital , kampala , uganda. 2010; 87 (10).
Cincotta RB, Brennecke SP. Family history of pre-eclampsia as a predictor for pre-eclampsia in primigravidas. Int J Gy- naecol Obstet [Internet]. 1998 Jan [cited 2014 Nov 25]; 60 (1):23–7. Available from: http://www.ncbi.nlm.nih.gov/ pubmed/9506410
Kiondo P, Wamuyu-Maina G, Bimenya GS, Tumwesigye NM, Wandabwa J, Okong P. Risk factors for pre-eclampsia in Mulago Hospital, Kampala, Uganda. Trop Med Int Health [Internet]. 2012 Apr [cited 2014 Oct 29]; 17 (4):480–7.
Sanchez SE, Zhang C, Qiu C-F, Williams MA. Family histo- ry of hypertension and diabetes in relation to preeclampsia risk in Peruvian women. Gynecol Obstet Invest [Internet]. 2003 Jan [cited 2014 Dec 19]; 56 (3):128–32. Available from: http://www.ncbi.nlm.nih.gov/pubmed/14530611
Hernández-Díaz S, Toh S, Cnattingius S. Risk of pre- eclampsia in first and subsequent pregnancies: prospective cohort study. BMJ [Internet]. 2009 Jan [cited 2014 Oct 30]; 338:b2255. Available from: http://www.pubmedcentral. nih.gov/articlerender.fcgi?artid=3269902&tool=pmcentrez &rendertype=abstract
Bilano VL, Ota E, Ganchimeg T, Mori R, Souza JP. Risk fac- tors of pre-eclampsia/eclampsia and its adverse outcomes in low- and middle-income countries: a WHO secondary analysis. Young RC, editor. PLoS One [Internet]. Public Li- brary of Science; 2014 Jan [cited 2014 Nov 21]; 9 (3):e91198. Available from: http://dx.plos.org/10.1371/journal.pone. 0091198
Sibai BM, Caritis S, Hauth J. What we have learned about preeclampsia. Semin Perinatol [Internet]. 2003 Jun [cited 2014 Oct 31]; 27 (3):239–46. Available from: http://linking hub.elsevier.com/retrieve/pii/S0146000503000223
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