Assessment of Thyroid Function Status and Thyroid Antibody Levels Among Tribal Population of Jarugumalai Hills of Salem District, Tamil Nadu, India

Vijayakarthikeyan M; Arul Prakash S; Prema Priya G; Angayarkanni P

doi:10.55489/njcm.151220244576

Authors

Vijayakarthikeyan M Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Affiliated to Vinayaka Missions Research Founda-tion (VMRF), Salem, Tamil Nadu, India
Arul Prakash S Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Affiliated to Vinayaka Missions Research Founda-tion (VMRF), Salem, Tamil Nadu, India
Prema Priya G Vinayaka Mission’s Kirupananda Variyar Medical College and Hospitals, Affiliated to Vinayaka Missions Research Founda-tion (VMRF), Salem, Tamil Nadu, India
Angayarkanni P Sri Devaraj URS Medical College, Affiliated to Sri Devaraj Academy of Higher Education and Research (SDUAHER), Kolar, Karnataka, India

DOI:

https://doi.org/10.55489/njcm.151220244576

Keywords:

Iodisation, Hypothyroidism, Goitre, Thyroiditis, Salt

Abstract

Background: Tribal population not only suffers from malnutrition and communicable diseases but also from non-communicable diseases. Globally, one of the most frequent metabolic disorders include thyroid disorders. The study was conducted to estimate the prevalence of Thyroid disorders using Thyroid Function Test, to determine the Anti-Thyroid Peroxidase Antibody levels among the tribal population, and also to determine the factors associated with thyroid disorders among the tribal population.

Materials and Methods: It is a community based analytical cross-sectional study conducted among 375 tribal residents of Jarugumalai hills. Data was collected using a pre tested semi-structured questionnaire. Categorical variables were described using frequency and percentage. Variables significantly associated with thyroid disorders were identified using univariate and multivariate analysis.

Results: Nearly 32% had any form of thyroid disorders. About 18% and 7% respectively had subclinical hypothyroidism and overt hypothyroidism. Also, 12% of the study participant blood samples were positive for Anti Thyroid Peroxidase antibody (ATPO). Female gender Usage of inadequately iodised salt and presence of ATPO were significantly associated with thyroid disorder on multivariate analysis.

Conclusion: Thyroid status assessment showed a high prevalence (32%) among the marginalized population. Multi-pronged approach involving educational, administrative and legal measures must be implemented to curb this problem.

References

Vanderpump MP. The epidemiology of thyroid disease. British medical bulletin. 2011 Sep 1;99(1). 39-51. DOI: https://doi.org/10.1093/bmb/ldr030 PMid:21893493

Ganie, M.A., Charoo, B.A., Sahar, T., Bhat, M.H., Ali, S.A., Niyaz, M., Sidana, S. and Yaseen, A., 2020. Thyroid function, urinary iodine, and thyroid antibody status among the tribal population of kashmir valley: data from endemic zone of a sub-Himalayan region. Frontiers in public health, 8, p.555840. DOI: https://doi.org/10.3389/fpubh.2020.555840 PMid:33194956 PMCid:PMC7655871

Unnikrishnan AG, Menon UV. Thyroid disorders in India: An epidemiological perspective. Indian journal of endocrinology and metabolism. 2011 Jul 1;15(Suppl2):S78-81. DOI: https://doi.org/10.4103/2230-8210.83329 PMid:21966658 PMCid:PMC3169866

Usha Menon V, Sundaram KR, Unnikrishnan AG, Jayakumar RV, Nair V, Kumar H. High prevalence of undetected thyroid disorders in an iodine sufficient adult south Indian population. J Indian Med Assoc 2009;107:72-7.

Zimmerman MB. Iodine deficiency. Endocr Rev 2009;30:376-408. DOI: https://doi.org/10.1210/er.2009-0011 PMid:19460960

MANJULA K, REENA R, JASWANTH S, USHA S. Thyroid Function and Anti-TPO Antibody Status among Tribal Perimenopausal Women Near Bengaluru, Karnataka, India. Journal of Clinical & Diagnostic Research. 2020 Oct 1;14(10). DOI: https://doi.org/10.7860/JCDR/2020/44793.14163

Marwaha RK, Tandon N, Ganie MA, Kanwar R, Sastry A, Garg MK, et al. Status of thyroid function in Indian adults: Two decades after universal salt iodisation. J Assoc Physicians of India. 2012;60:32-36.

Kumar MM, Pathak VK, Manisha RJ. Tribal population in India: A public health challenge and road to future. J Fam Med Prim Care. 2020;9(2):508-12. DOI: https://doi.org/10.4103/jfmpc.jfmpc_992_19 PMid:32318373 PMCid:PMC7113978

Roy S, Hegde HV, Bhattacharya D, Upadhya V, Kholkute SD. Tribes in Karnataka: Status of health research. Indian J Med Research. 2015;141(3):673-87.

Chatterjee S, Banerjee S, Ray T, Bhattacharyya SK. Relationship of Thyroid Hormone Status and Serum Fluoride Level among the Tribal Peoples-A Cross-sectional Descriptive Study. Journal of Medical Science and Clinical Research. 2016 June;4(6):11143-47.

Akinepalli P, Badam A, Vithpala P, Bandaru AK. Prevalence of Thyroid Disorders in and around Nalgonda District, Telangana, India: A Cross-sectional Study. National Journal of Laboratory Medicine. 2023;12(3):20-24. DOI: https://doi.org/10.7860/NJLM/2023/59070.2694

Dhok AJ, Adole PS, Puppalwar PV, Agrawal U. Status of Thyroid disorders at Acharya Vinobha Bhave Rural Hospital, Sawangi (Meghe), Wardha, India. Thyroid Research and Practice. 2015 May 1;12(2):62-6. DOI: https://doi.org/10.4103/0973-0354.153342

Chakrabarti P, Chatterjee S, Mondal K, Banerjee S, Sarkar P. Spectrum of Thyroid Disorders In Bankura District, West Bengal, India: A Cross-Sectional Observational Study. IOSR Journal of Dental and Medical Sciences. 2016;15(07):41-4. DOI: https://doi.org/10.9790/0853-150734144

Valiyaparambil PP, Menon UV, Lakshmanan V, Vasudevan S, Kumari A, Kumar H. Iodine And Thyroid Status in A Tribal Village in Wayanad, Kerala in The Post Iodization Era-Observations and Implications. National Journal of Community Medicine. 2013 Mar 31;4(01):86-90.

Bansal A, Kaushik A, Sarathe H. Effect of thyroid on lipid profile and renal function: an observational study from tertiary care centre of tribal region of Bastar. Annals of Medical and Health Sciences Research. 2014;4(8):140-3. DOI: https://doi.org/10.4103/2141-9248.138035 PMid:25184081 PMCid:PMC4145511

Skaria LK, Sarkar PD, Agnihotram G, Thakur AS, Pamidamarri G. Thyroid Dysfunctions in Tribal Women of the Bastar Region of Chattisgharh, India. Thyroid Sci. 2011;6(6):1-5.

Arakeri S, Vasu G. Correlation of anti-thyroid peroxidase antibody levels with status of thyroid function among the tribal population residing in hilly area. J Diagn Pathol Oncol. 2016 Oct;1:21-3.

Baruah MP, Duttachoudhury S, Saikia M, Saikia UK, Bhuyan SB, Bhowmick A, Barman AK, Bora AR, Barkakoti M. Guwahati thyroid epidemiology study: High prevalence of primary hypothyroidism among the adult population of Guwahati city. Thyroid Research and Practice. 2019 Jan 1;16(1):12-9. DOI: https://doi.org/10.4103/trp.trp_5_19

Bulliyya G, Dwibedi B, Mallick G, Sethy PG, Kar SK. Determination of iodine nutrition and community knowledge regarding iodine deficiency disorders in selected tribal blocks of Orissa, India. Journal of Pediatric Endocrinology and Metabolism. 2008 Jan;21(1):79-88. DOI: https://doi.org/10.1515/JPEM.2008.21.1.79 PMid:18404976