Chemoprophylaxis Status among Medical Practitioners Involved In the Care of COVID19 Suspects/Confirmed Cases in Karnataka

Authors

  • Apoorva E Patel AIMS&RC, Devanahalli, Bengaluru
  • Srividya J AIMS&RC, Devanahalli, Bengaluru
  • Sunil Kumar DR AIMS&RC, Devanahalli, Bengaluru

DOI:

https://doi.org/10.5455/njcm.20210614073630

Keywords:

COVID-19, Chemoprophylaxis, Medical practitioners, adverse events

Abstract

Background: In the ongoing pandemic of Covid-19 health care workers are at high risk of getting infected. The National task force for COVID-19 constituted by ICMR recommended the use of hydroxyl chloroquine as prophylaxis for healthcare workers. This study conducted to determine the status of chemoprophylaxis and protectiveness of chemoprophylaxis among medical practitioners in Karnataka, involved in the care of COVID19 suspects/confirmed cases.

Methods: A cross-sectional study was carried out using a pretested online questionnaire among 236 Medical Practitioners (both government and private) involved in COVID- 19 care, across Karnataka, between June August 2020.

Results: Out of 236 Medical Practitioners, 118 responded and 100 Medical Practitioners responded completely, majority were males (69%), aged 31-50 years (58%), working at private health care setups (74%). Out of this, 46% took the chemoprophylaxis, 26% experienced side effects. 27 (59%)had Completed chemoprophylaxis. After completion Of Chemoprophylaxis, 16(89%) were tested negative, indicating good protectiveness and 2 (11%) tested positive. The difference in completion of chemoprophylaxis among government (15[79%)] and private doctors (12[44%)] was found to be statistically significant. Statistically significant association was also seen with age, gender, experience in years.

Conclusion: Chemoprophylaxis has good protectiveness. Majority did not take chemoprophylaxis for fear of adverse events.

References

World Health Organization. Situation Report –COVID 19. [cited on 2020 Dec 28]; Available from: https://www.who.int/ emergencies/coronavirus-disease-(covid-19)/-situation-report

Revised advisory on the use of Hydroxychloroquine (HCQ) as prophylaxis for SARS –CoV – 2 infection. Indian Council of Medical Research, Ministry of Health and Family Welfare, Government of India . Dated 22nd May 2020. [cited on 2020 Dec 28]; Available from: https://www.mohfw.gov.in/pdf/Revised AdvisoryontheuseofHydroxychloroquineasprophylaxisfor-SARSCoV2infection.pdf

Yao, X et al. In Vitro Antiviral Activity and Projection of Opti-mized Dosing Design of Hydroxychloroquine for the Treat-ment of Severe Acute Respiratory SyndromeCoronavirus 2 (SARS-CoV2).Clin Infect Dis 2020. 71(15):p 732-739.

Liu Jet al. Hydroxychloroquine , a less toxic derivative of chlo-roquine, is effective inhibiting SARS CoV 2 infection in vitro, Cell discovery 2020 6(1):p 1-4.

Boulware DR et al. A Randomized Trial of Hydroxychloroquine as Postexposure Prophylaxis for COVID 19. N Engl J Med 2020 383(6):p517 -525.

Cavalcanti et al. Hydroxychloroquine with or without Azith-romycin in Mild to Moderate COVID 19. N Engl J Med 2020.

ICMR- “Recommendation for use of hydroxy-chloroquine for prophylaxis of SARS - CoV - 2 infection” https://icmr.nic.in/ sites/default/files/upload_documents/HCQ_Recommendation_22M arch_final_MM.pdf (Accessed on 28 May 2020)

8. Shah K, Kamrai D, Mekala H, Mann B, Desai K, Patel RS. Focus on Mental Health During the Coronavirus (COVID-19) Pandemic: Applying Learnings from the Past Outbreaks. Cureus. 2020;DOI:10.7759/cureus.7405

9. Wang C, Pan R, Wan X, Tan Y, Xu L, Ho CS, et al. Immediate psychological responses and associated factors during the initial stage of the 2019 coronavirus disease (COVID-19) epidemic among the general population in China. Int J Environ Res Public Health. 2020;DOI:10.3390/ijerph17051729

10. Li W, Yang Y, Liu ZH, Zhao YJ, Zhang Q, Zhang L, et al. Progression of Mental Health Services during the COVID-19 Outbreak in China. International journal of biological sciences. 2020. DOI: 10.7150/ijbs.45120

11. Lima CKT, Carvalho PM de M, Lima I de AAS, Nunes JVA de O, Saraiva JS, de Souza RI, et al. The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease). Psychiatry Research. 2020. DOI:10.1016/j.psychres.2020.112915

Dan Zhou S-MDQT. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression | Journal of Antimicrobial Chemotherapy | Oxford Academic. J Antimicrob Chemother. 2020; DOI:10.1093/jac/ dkaa114

Noël F, Lima J. Pharmacological aspects and clues for the rational use of Chloroquine / Hydroxychloroquine facing the therapeutic challenges of COVID-19 pandemic. Lat Am J Clin Sci Med Technol. 2020; Apr; 2: 28-34 12.

Driggin E, Madhavan M V., Bikdeli B, Chuich T, Laracy J, Biondi-Zoccai G, et al. Cardiovascular Considerations for Patients, Health Care Workers, and Health Systems During the COVID-19 Pandemic. Journal of the American College of Cardiology. 2020. DOI:10.1016/j.jacc.2020.03.031

Ponticelli C, Moroni G. Hydroxychloroquine in systemic lupus erythematosus (SLE). Expert Opin Drug Saf. 2017. doi:10.1080 /14740338.2017.1269168

Ochsendorf FR, Runne U. Chloroquine and hydroxychloroquine: Side-effect profile of important drugs. Hautarzt. 1991.

Dan Zhou S-MDQT. COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression | Journal of Antimicrobial Chemotherapy | Oxford Academic. J Antimicrob Chemother. 2020.

Ahluwalia J, Brooks SK, Weinman J, Rubin GJ. A systematic review of factors affecting adherence to malaria chemoprophylaxis amongst travellers from nonendemic countries. Malar J. 2020. doi:10.1186/s12936-020-3104-4

19. Jacquerioz FA, Croft AM. Drugs for preventing malaria in travellers. Cochran Database Syst Rev. 2015. doi:10.1002/14651858.CD006491.pub3e

Tickell-Painter M, Maayan N, Saunders R, Pace C, Sinclair D. Mefloquine for preventing malaria during travel to endemic areas. Cochrane Database Syst Rev. 2017. doi:10.1002/ 14651858.CD006491.pub4

21. Drugs to Prevent Malaria in Travellers: A Systematic Review of Randomized Controlled Trials. Hum Parasit Dis. 2010. doi:10.4137/hpd.s4223

Gupta A, Kakkar R. Managing a covid 19 patient at different health care and field level settings. Indian J Community Heal. 2020.

Patrì A, Fabbrocini G. Hydroxychloroquine and ivermectin: A synergistic combination for COVID-19 chemoprophylaxis and treatment? J Am Acad Dermatol. 2020. doi:10.1016/j.jaad.2020.04.017

Napoli PE, Nioi M. Global Spread of Coronavirus Disease 2019 and Malaria: An Epidemiological Paradox in the Early Stage of A Pandemic. J Clin Med. 2020. doi:10.3390/jcm9041138

Al-Kofahi M, Jacobson P, Boulware D, et al. Finding the dose for hydroxychloroquine prophylaxis for COVID-19; the desperate search for effectiveness. Clin Pharmacol Ther. 2020. doi:10.1111/gcb.14887

Etienne CHU de Saint, Pasteur I. Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers. ClinicalTrials. 2020.

Nioi M, Napoli PE. Global Spread of Coronavirus Disease 2019 and Malaria: An Epidemiological Paradox. SSRN Electron J. 2020. doi:10.2139/ssrn.3554389

Rios P, Radhakrishnan A, Thomas SM, Darvesh N, Straus SE, Tricco AC. Guidelines for preventing respiratory illness in older adults aged 60 years and above living in long-term care: A rapid review of clinical practice guidelines. medRxiv. 2020. doi:10.1101/2020.03.19.20039180

Arshad U, Pertinez H, Box H, et al. Prioritisation of potential anti-SARS-CoV-2 drug repurposing opportunities based on ability to achieve adequate target site concentrations derived from their established human pharmacokinetics. medRxiv. 2020. doi:10.1101/2020.04.16.20068379

Carme B, Peguet C, Nevez G. Compliance with and tolerance of mefloquine and chloroquine + proguanil malaria chemoprophylaxis in French short-term travellers to sub-Saharan Africa. Trop Med Int Health. 1997;2(10):953

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Published

2021-06-30

How to Cite

1.
Patel AE, Srividya J, Kumar DR S. Chemoprophylaxis Status among Medical Practitioners Involved In the Care of COVID19 Suspects/Confirmed Cases in Karnataka. Natl J Community Med [Internet]. 2021 Jun. 30 [cited 2024 Nov. 13];12(06):121-6. Available from: https://njcmindia.com/index.php/file/article/view/369

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Original Research Articles