COVID-19 Vaccine Breakthrough Infections Among Healthcare Workers in A Tertiary Care Hospital in Coastal Karnataka, India – A Prospective Cohort Study

Nanjesh  Kumar S; Amit Kumar Rao; Lavannya Mary  Thayil

doi:10.55489/njcm.150320243620

Authors

Nanjesh Kumar S K S Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India
Amit Kumar Rao K S Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India
Lavannya Mary Thayil K S Hegde Medical Academy, NITTE (Deemed to be University), Mangalore, India

DOI:

https://doi.org/10.55489/njcm.150320243620

Keywords:

COVID-19, COVID-19 vaccination, COVID-19 vaccine breakthrough infection, Healthcare worker

Abstract

Background: The COVID-19 pandemic resulted in significant mortality and morbidity globally. The introduction of various COVID-19 vaccines at record time generated hope among people and doubts and apprehension regarding their safety. The study was done to estimate the incidence of COVID-19 vaccine breakthrough infections among Health Care Workers working in a tertiary care hospital and evaluate the outcome of these infections.

Methods: A prospective Cohort study was conducted among 6342 healthcare workers in a tertiary care hospital having received at least one dose of any COVID-19 vaccine. They were followed up for COVID-19 vaccine breakthrough infection for one year by epidemiological investigations. Data on COVID-19-positive healthcare workers was obtained through personal interviews and case records.

Results: 490 (7.9%) developed COVID-19 vaccine breakthrough infection during the study period. The majority of them (96.7%) were asymptomatic, and 16 (3.3%) of them developed complications needing hospitalization with 2 deaths. A statistically significant association was found in sex, healthcare worker categories, co-morbidities, and Blood groups.

Conclusion: COVID-19 vaccination among healthcare workers reduces the incidence, severity, and complications of COVID-19 vaccine breakthrough infections. The risk of acquiring COVID-19 vaccine breakthrough infections was higher among males, partially vaccinated individuals, people with co-morbidities, and those involved in the regular care of COVID-19 patients. COVID-19-appropriate behaviour and receiving all the primary doses of vaccine will be instrumental in COVID-19 control.

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