Survival Analysis in Oral Cancer Patients: A Reliable Statistical Analysis Tool

Authors

  • Nihar Ranjan Panda IMS & SUM Hospital, SOA Deemed to be University, Bhubaneswar, India
  • Devipriya Gouda Institute of dental science, SOA Deemed to be University, Bhubaneswar, India
  • Sanat Kumar Bhuyan Institute of dental science, SOA Deemed to be University, Bhubaneswar, India
  • Ruchi Bhuyan IMS & SUM Hospital, SOA Deemed to be University, Bhubaneswar, India

DOI:

https://doi.org/10.55489/njcm.141120233384

Keywords:

Oral cancer, Survival analysis, Survival Rate, Cox Regression, Hazard Ratio

Abstract

Clinical trials or follow-up studies sometimes necessitate the long-term monitoring of patients, with an emphasis on crucial events such as mortality, recurrence, severe medication responses, or the advent of new illnesses. These studies cover a range of follow-up times, from a few weeks to several years. Analyzing such data necessitates the use of specialized statistical approaches such as time-to-event analysis and survival analysis. This method is extremely useful in clinical research, providing crucial insights into therapies. The three basic purposes of survival analysis are to determine and analyze survival/hazard functions using survival data, compare these functions, and evaluate how explanatory factors relate to survival time. This methodology is useful for investigating event timing in a variety of situations, notably in clinical studies where event-based data is common. This paper is intended to serve as a primer for researchers, exposing them to the wide range of methods accessible in the discipline of survival analysis. Researchers have the ability to traverse the complex terrain of clinical trial data distinguished by variable follow-up durations, by diving into this approach. The key to survival analysis is its capacity to provide subtle insights into the temporal elements of patient reactions, providing a full view of intervention success. We have taken the cases of oral cancer survival analysis studies and put a light on methods and association used there.

References

Sankaranarayanan R, Ramadas K, Amarasinghe H, Subramanian S, Johnson N. Oral cancer: prevention, early detection, and treat-ment. Cancer: disease control priorities, third edition (volume 3). 2015 Nov 1. Doi: https://doi.org/10.1596/978-1-4648-0349-9_ch5 PMid:26913350

Hussein AA, Helder MN, de Visscher JG, Leemans CR, Braakhuis BJ, de Vet HC, Forouzanfar T. Global incidence of oral and orophar-ynx cancer in patients younger than 45 years versus older patients: A systematic review. European Journal of Cancer. 2017 Sep 1;82:115-27. Doi: https://doi.org/10.1016/j.ejca.2017.05.026 PMid:28654785

Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma-an update. CA: a cancer journal for clinicians. 2015 Sep;65(5):401-21. Doi: https://doi.org/10.3322/caac.21293 PMid:26215712

Gopinath D, Kunnath Menon R, K. Veettil S, George Botelho M, Johnson NW. Periodontal diseases as putative risk factors for head and neck cancer: systematic review and meta-analysis. Cancers. 2020 Jul 14;12(7):1893. Doi: https://doi.org/10.3390/cancers12071893 PMid:32674369 PMCid:PMC7409086

Christianto S, Li KY, Huang TH, Su YX. The Prognostic Value of Human Papilloma Virus Infection in Oral Cavity Squamous Cell Carci-noma: A Meta‐Analysis. The Laryngoscope. 2022 Sep;132(9):1760-70. Doi: https://doi.org/10.1002/lary.29996 PMid:34953144

Razak AA, Saddki N, Naing NN, Abdullah N. Oral cancer survival among Malay patients in Hospital Universiti Sains Malaysia, Kelan-tan. Asian Pac J Cancer Prev. 2010 Jan 1;11(1):187-91.

Cavallo D, Ursini CL, Fresegna AM, Maiello R, Ciervo A, Ferrante R, Buresti G, Iavicoli S. Cyto-genotoxic effects of smoke from com-mercial filter and non-filter cigarettes on human bronchial and pulmonary cells. Mutation Research/Genetic Toxicology and Envi-ronmental Mutagenesis. 2013 Jan 20;750(1-2):1-1. Doi: https://doi.org/10.1016/j.mrgentox.2012.06.013 PMid:23010388

Mehta H, Nazzal K, Sadikot RT. Cigarette smoking and innate immunity. Inflammation Research. 2008 Nov;57:497-503. Doi: https://doi.org/10.1007/s00011-008-8078-6 PMid:19109742

Burke HB, Henson DE. Criteria for prognostic factors and for an enhanced prognostic system. Cancer. 1993 Nov 15;72(10):3131-5. Doi: https://doi.org/10.1002/1097-0142(19931115)72:10<3131::AID-CNCR2820721039>3.0.CO;2-J PMid:8221580

Piccirillo JF, Feinstein AR. Clinical symptoms and comorbidity: significance for the prognostic classification of cancer. Cancer: In-terdisciplinary International Journal of the American Cancer Society. 1996 Mar 1;77(5):834-42. Doi: https://doi.org/10.1002/(SICI)1097-0142(19960301)77:5<834::AID-CNCR5>3.0.CO;2-E

Piccirillo JF. Importance of comorbidity in head and neck cancer. The Laryngoscope. 2000 Apr;110(4):593-602. Doi: https://doi.org/10.1097/00005537-200004000-00011 PMid:10764003

Xing Y, Zhang J, Lin H, Gold KA, Sturgis EM, Garden AS, Lee JJ, William Jr WN. Relation between the level of lymph node metastasis and survival in locally advanced head and neck squamous cell carcinoma. Cancer. 2016 Feb 15;122(4):534-45. Doi: https://doi.org/10.1002/cncr.29780 PMid:26554754 PMCid:PMC4742373

Li W, Sanki A, Karim RZ, Thompson JF, Soon Lee C, Zhuang L, McCarthy SW, Scolyer RA. The role of cell cycle regulatory proteins in the pathogenesis of melanoma. Pathology. 2006 Jan 1;38(4):287-301. Doi: https://doi.org/10.1080/00313020600817951 PMid:16916716

Flynn R. Survival analysis. Journal of Clinical Nursing. 2012 Oct;21(19pt20):2789-97. Doi: https://doi.org/10.1111/j.1365-2702.2011.04023.x PMid:22860755

Altman DG, De Stavola BL, Love SB, Stepniewska KA. Review of survival analyses published in cancer journals. British journal of cancer. 1995 Aug;72(2):511-8. Doi: https://doi.org/10.1038/bjc.1995.364 PMid:7640241 PMCid:PMC2033978

Zhu Y, Zhou C, He Q. Radiation therapy's efficacy on tongue cancer: a population-based survival analysis. OncoTargets and therapy. 2018 Oct 23:7271-6. Doi: https://doi.org/10.2147/OTT.S169231 PMid:30425518 PMCid:PMC6205818

Yanik EL, Katki HA, Silverberg MJ, Manos MM, Engels EA, Chaturvedi AK. Leukoplakia, oral cavity cancer risk, and cancer survival in the US elderly. Cancer Prevention Research. 2015 Sep 1;8(9):857-63. Doi: https://doi.org/10.1158/1940-6207.CAPR-15-0091 PMid:26159805 PMCid:PMC4560597

Oliveira LR, Ribeiro-Silva A, Costa JP, Simões AL, Di Matteo MA, Zucoloto S. Prognostic factors and survival analysis in a sample of oral squamous cell carcinoma patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2008 Nov 1;106(5):685-95. Doi: https://doi.org/10.1016/j.tripleo.2008.07.002 PMid:18760943

Warnakulasuriya S, Mak V, Möller H. Oral cancer survival in young people in South East England. Oral oncology. 2007 Nov 1;43(10):982-6. Doi: https://doi.org/10.1016/j.oraloncology.2006.11.021 PMid:17350878

Wong YK, Tsai WC, Lin JC, Poon CK, Chao SY, Hsiao YL, Chan MY, Cheng CS, Wang CC, Wang CP, Liu SA. Socio-demographic factors in the prognosis of oral cancer patients. Oral oncology. 2006 Oct 1;42(9):893-906. Doi: https://doi.org/10.1016/j.oraloncology.2005.12.007 PMid:16730220

Sharma K, Ahlawat P, Gairola M, Tandon S, Sachdeva N, Sharief MI. Prognostic factors, failure patterns and survival analysis in pa-tients with resectable oral squamous cell carcinoma of the tongue. Radiation Oncology Journal. 2019 Jun;37(2):73. Doi: https://doi.org/10.3857/roj.2018.00577 PMid:31266288 PMCid:PMC6610009

Moro JD, Maroneze MC, Ardenghi TM, Barin LM, Danesi CC. Oral and oropharyngeal cancer: epidemiology and survival analysis. Ein-stein (Sao Paulo). 2018 Jun 7;16. Doi: https://doi.org/10.1590/s1679-45082018ao4248 PMid:29898090 PMCid:PMC5995547

Geleijnse G, Chiang RC, Sieswerda M, Schuurman M, Lee KC, van Soest J, Dekker A, Lee WC, Verbeek XA. Prognostic factors analysis for oral cavity cancer survival in the Netherlands and Taiwan using a privacy-preserving federated infrastructure. Scientific re-ports. 2020 Nov 25;10(1):20526. Doi: https://doi.org/10.1038/s41598-020-77476-2 PMid:33239719 PMCid:PMC7688977

Farquhar DR, Tanner AM, Masood MM, Patel SR, Hackman TG, Olshan AF, Mazul AL, Zevallos JP. Oral tongue carcinoma among young patients: An analysis of risk factors and survival. Oral oncology. 2018 Sep 1;84:7-11. Doi: https://doi.org/10.1016/j.oraloncology.2018.06.014 PMid:30115478

Bell EB, Reis IM, Cohen ER, Almuhaimid T, Smith DH, Alotaibi F, Gordon C, Gomez-Fernandez C, Goodwin WJ, Franzmann EJ. Green salad intake is associated with improved oral cancer survival and lower soluble CD44 levels. Nutrients. 2021 Jan 26;13(2):372. Doi: https://doi.org/10.3390/nu13020372 PMid:33530399 PMCid:PMC7911809

Agarwal P, Agrawal RR, Jones EA, Devaiah AK. Social determinants of health and oral cavity cancer treatment and survival: a com-peting risk analysis. The Laryngoscope. 2020 Sep;130(9):2160-5. Doi: https://doi.org/10.1002/lary.28321 PMid:31654440

Chandu A, Adams G, Smith AC. Factors affecting survival in patients with oral cancer: an Australian perspective. International jour-nal of oral and maxillofacial surgery. 2005 Jul 1;34(5):514-20. Doi: https://doi.org/10.1016/j.ijom.2004.10.006 PMid:16053871

Yeole BB, Ramanakumar AV, Sankaranarayanan R. Survival from oral cancer in Mumbai (Bombay), India. Cancer Causes & Control. 2003 Dec;14:945-52. Doi: https://doi.org/10.1023/B:CACO.0000007965.61579.b2 PMid:14750533

Zeljic K, Supic G, Stamenkovic Radak M, Jovic N, Kozomara R, Magic Z. Vitamin D receptor, CYP27B1 and CYP24A1 genes polymor-phisms association with oral cancer risk and survival. Journal of oral pathology & medicine. 2012 Nov;41(10):779-87. Doi: https://doi.org/10.1111/j.1600-0714.2012.01164.x PMid:22612324

Mendez E, Houck JR, Doody DR, Fan W, Lohavanichbutr P, Rue TC, Yueh B, Futran ND, Upton MP, Farwell DG, Heagerty PJ. A genetic expression profile associated with oral cancer identifies a group of patients at high risk of poor survival. Clinical Cancer Research. 2009 Feb 15;15(4):1353-61. Doi: https://doi.org/10.1158/1078-0432.CCR-08-1816 PMid:19228736 PMCid:PMC2683360

Cheraghlou S, Schettino A, Zogg CK, Judson BL. Changing prognosis of oral cancer: An analysis of survival and treatment between 1973 and 2014. The Laryngoscope. 2018 Dec;128(12):2762-9. Doi: https://doi.org/10.1002/lary.27315 PMid:30194691

Choi YS, Kim MG, Lee JH, Park JY, Choi SW. Analysis of prognostic factors through survival rate analysis of oral squamous cell carci-noma patients treated at the National Cancer Center: 20 years of experience. Journal of the Korean Association of Oral and Maxillofa-cial Surgeons. 2022 Oct 1;48(5):284-91. DOI: Doi: https://doi.org/10.5125/jkaoms.2022.48.5.284 PMid:36316186 PMCid:PMC9639249

Kung LY, Li TI, Chung CH, Lee SP, Chen GS, Chien WC, Tzeng NS. Risk of depression in patients with oral cancer: a nationwide cohort study in Taiwan. Scientific Reports. 2021 Dec 7;11(1):23524. Doi: https://doi.org/10.1038/s41598-021-02996-4 PMid:34876632 PMCid:PMC8651796

Sakamoto Y, Otsuru M, Hasegawa T, Akashi M, Yamada SI, Kurita H, Okura M, Yamakawa N, Kirita T, Yamamoto S, Umeda M. Treat-ment and Prognosis of Oral Cancer Patients with Confirmed Contralateral Neck Metastasis: A Multicenter Retrospective Analysis. International Journal of Environmental Research and Public Health. 2022 Jul 28;19(15):9229. Doi: https://doi.org/10.3390/ijerph19159229 PMid:35954583 PMCid:PMC9368347

Zanoni DK, Montero PH, Migliacci JC, Shah JP, Wong RJ, Ganly I, Patel SG. Survival outcomes after treatment of cancer of the oral cavi-ty (1985-2015). Oral oncology. 2019 Mar 1;90:115-21. Doi: https://doi.org/10.1016/j.oraloncology.2019.02.001 PMid:30846169 PMCid:PMC6417804

Varela-Centelles PI, Fernández EV, Asenjo JG. Survival to oral cancer. A study of clinical risk markers with independent prognostic value. Bulletin du GIRSO. 2002;44(2):46-51.

Karnov KK, Grønhøj C, Jensen DH, Wessel I, Charabi BW, Specht L, Kjaer A, von Buchwald C. Increasing incidence and survival in oral cancer: a nationwide Danish study from 1980 to 2014. Acta Oncologica. 2017 Sep 2;56(9):1204-9. Doi: https://doi.org/10.1080/0284186X.2017.1307516 PMid:28366106

Megwalu UC, Ma Y. Racial disparities in oropharyngeal cancer survival. Oral Oncology. 2017 Feb 1;65:33-7. Doi: https://doi.org/10.1016/j.oraloncology.2016.12.015 PMid:28109465

Fang KH, Kao HK, Cheng MH, Chang YL, Tsang NM, Huang YC, Lee LY, Yu JS, Hao SP, Chang KP. Histological differentiation of primary oral squamous cell carcinomas in an area of betel quid chewing prevalence. Otolaryngology-Head and Neck Surgery. 2009 Dec;141(6):743-9. Doi: https://doi.org/10.1016/j.otohns.2009.09.012 PMid:19932848

Oguejiofor KK, Hall JS, Mani N, Douglas C, Slevin NJ, Homer J, Hall G, West CM. The prognostic significance of the biomarker p16 in oropharyngeal squamous cell carcinoma. Clinical oncology. 2013 Nov 1;25(11):630-8. Doi: https://doi.org/10.1016/j.clon.2013.07.003 PMid:23916365

Abati S, Bramati C, Bondi S, Lissoni A, Trimarchi M. Oral cancer and precancer: a narrative review on the relevance of early diagno-sis. International journal of environmental research and public health. 2020 Dec;17(24):9160. Doi: https://doi.org/10.3390/ijerph17249160 PMid:33302498 PMCid:PMC7764090

Bhuyan, R., Bhuyan, S. K., Panda, N. R., & Mohanty, J. (2022). Age and gender demographic and statistical analysis in oral squamous cell carcinoma in Eastern India. Journal of Associated Medical Sciences, 56(1), 35-39. Doi: https://doi.org/10.12982/JAMS.2023.005

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Published

2023-11-01

How to Cite

1.
Panda NR, Gouda D, Bhuyan SK, Bhuyan R. Survival Analysis in Oral Cancer Patients: A Reliable Statistical Analysis Tool. Natl J Community Med [Internet]. 2023 Nov. 1 [cited 2024 Nov. 21];14(11):745-51. Available from: https://njcmindia.com/index.php/file/article/view/3384

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Review Articles