Breast Cancer Is Significantly Associated with Cancers in The First- and Second-Degree Relatives in Ethnic Mizo-Mongoloid Population, Northeast India

Doris  Zodinpuii; Jeremy Lalrinsanga  Pautu; Bawitlung  Zothankima; Lalfakzuala  Khenglawt; Doris  Lallawmzuali; Rebecca  Lalmuanpuii; Lalfak  zuali; Lalengkimi  Ralte; Rajendra Bose  Muthukumaran; Ashok Kumar Varma; John  Zothanzama; Nachimuthu Senthil Kumar

doi:10.55489/njcm.130920222120

Authors

Doris Zodinpuii Mizoram University, Mizoram, India
Jeremy Lalrinsanga Pautu Mizoram State Cancer Institute, Mizoram, India
Bawitlung Zothankima Mizoram State Cancer Institute, Mizoram, India
Lalfakzuala Khenglawt Mizoram State Cancer Institute, Mizoram, India
Doris Lallawmzuali Mizoram State Cancer Institute, Mizoram, India
Rebecca Lalmuanpuii Mizoram University, Mizoram, India
Lalfak zuali Mizoram University, Mizoram, India
Lalengkimi Ralte Mizoram University, Mizoram, India
Rajendra Bose Muthukumaran Mizoram University, Mizoram, India
Ashok Kumar Varma Advanced Centre for Treatment, Research and Education in Cancer, Navi Mumbai, India
John Zothanzama Mizoram University, Mizoram, India
Nachimuthu Senthil Kumar Mizoram University, Mizoram, India

DOI:

https://doi.org/10.55489/njcm.130920222120

Keywords:

Dietary habits, Family history, Inheritable disease, Lifestyle habits, Smoked and fermented food

Abstract

Background: High incidence of breast cancer among the endogamous Mizo-Mongoloid tribe stresses the need to explore the disease pertaining to the family history as well as other risk factors. This study investigates the association of risk factors and inherited diseases with breast cancer.

Methodology: The study includes 426 unrelated breast cancer cases and 810 healthy controls of female Mizo ethnicity. Association between reproductive history, lifestyle/ dietary habits, tobacco and alcohol exposures, family history in relation to cancer and inheritable diseases was assessed by univariate logistic regression using Chi-square tests and multivariate analyses using Cox regression.

Results: Age at diagnosis was highest between 41 to 50 years. Consumption of fermented pork fat, smoked food and Smoke-less tobacco, lower intake of vegetables/ water, having a first/ or second degree relative with cancers and inheritable diseases were found to be the major risk factors. Certain known factors were also acting as confounding factors.

Conclusions: The present study reveals that Mizo women with first- and second-degree relatives of breast cancer, various other cancers and inheritable diseases have increased risk of breast cancer. This study also highlights the importance of analysing genetic factors which can aid in early detection of inherited risk factors.

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