Determinants Of Survival Among Patients with Cervical Cancer: A Hospital Based Study
Keywords:
Cervical cancer, survival, modifiable factor, followupAbstract
Introduction: Cervical cancer is the fourth most common cancer among women worldwide and India contributes largest propor- tion to it. As per Globacon 2012 there were 1,23,000 cases and 67,000 deaths due to cervical cancer in India. Studies directed to- wards identifying the factors determining survival will help poli- cy makers in designing the strategies for prolonging the life of these patients. Objective of the study was to assess the factors de- termining survival among patients with cervical cancer.
Methodology: This combined prospective and retrospective study was conducted during January 2012- December 2012 (One year) among all the newly diagnosed cases of cervical cancer from January 2006 to December 2007 at a tertiary care cancer hospital. Baseline data was collected by reviewing the medical records and cases were followed up for the next five years from the date of diagnosis to assess their survival status.
Results: Among 380 patients included in the study, overall five year survival rate was found to be 48.1%, 38.7% had lost their life and 13.2 % lost to follow up. Age at diagnosis, education, perfor- mance status at presentation, staging (p = 0.001), parity, tobacco chewing (p< 0.01) and age at menopause (p = 0.05) were signifi- cantly associated with survival.
Conclusion: Five year survival rate for cervical cancer was found to be 48.1%. Various factors determining survival were potentially modifiable.
References
International Agency for Research on Cancer, WHO.GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Available at: http://globocan.iarc.fr/pages/fact-sheets- cancer.aspx (last accessed on March 2, 2015).
International Collaboration of Epidemiological Studies of Cervical Cancer. Comparison of risk factors for inva- sive squamous cell carcinoma and adenocarcinoma of the cervix: collaborative reanalysis of individual data on 8,097 women with squamous cell carcinoma and 1,374 women with adenocarcinoma from 12 epidemiological studies. Int J Cancer.2007;120(4):885-91.
Franceschi S, Plummer M, Clifford G, Sanjose S, Bosch X, Herrero R et al. Differences in the risk of cervical can- cer and human papilloma virus infection by education level. Br J Cancer.2009;101:865 –70.
Green J, Berrington G, Sweetland S, Beral V,Chilvers C, Crossley B et al. Risk factors for adenocarcinoma and squamous cell carcinoma of the cervix in women aged 20–44 years: the UK National Case Control Study of Cervical Cancer. Br J Cancer.2003; 89: 2078 –86.
Rajkumar T, Franceschi S, Vaccarella S, Gajalakshmi V, Sharmila A, Snijders PJF et al. Role of paan chewing and dietary habits in cervical carcinoma in Chennai, India. Br J Cancer.2003; 88:1388 -93.
Sankaranarayanan R, Swaminathan R, Brenner H, Chen K, Chia SK, Chen GJ et al. Cancer survival in Africa, Asia, and Central America: a population-based study. Lancet Oncol. 2010; 11:165–73.
Patil V, Wahab SN, Zodpey S, Vasudeo ND. Develop- ment and validation of risk scoring system for predic- tion of cancer cervix. IJPH.2006;50:38-41.
Chhabra S, Bhavani M, Mahajan N, Bawaskar R.Cervical cancer in Indian rural women: trends over two decades.J Obstet Gynaecol.2010; 30:5-8.
All India Consumer Price Index 2012. Available at: http://cyberjournalist.org.in/manisana/aicpinew.html (last accessed on july 12, 2012).
Petterson F. Annual report on the results of treatment in gynaecological cancer. Radiumhemmet, Stockholm, Sweden: International Federation of Gynaecology and Obstetrics (FIGO); 1994: 132-68.
Cancer of the cervix uteri.Availableat:http://seer.cancer.gov/stat facts/html/cervix. html (last accessed on August 8,2013).
Yeole BB, Kurkure AP, Sunny L. Cancer survival in Mumbai (Bombay), India, 1992- 1999. Lyon, France. In- ternational Agency for Research on Cancer, World Health Organization; 2011. p 133- 142. IARC Scientific Publications No.162. URL available at http://survcan.iarc.fr
Sankaranarayanan R, Nair KM, Jayaprakash PG, Stanley G, Varghese C, Ramadas V et al. Cervical cancer in Kerala: a hospital registry based study on survival and prognostic factors. Br J Cancer.1995; 72:1039-42.
Swaminathan R, Rama R, Nalini S, Shantha V. Cancer survival in Chennai (Madras), India, 1990- 1999. Lyon, France. International Agency for Research on Cancer, World Health Organization; 2011. p 115- 124. IARC Sci- entific Publications No.162. URL available at http://survcan.iarc.fr
National Cancer Registry Programme (NCRP), Indian Council of Medical Research (ICMR). An assessment of the burden and care of cancer patients: Consolidated re- port of hospital based cancer registries, 2001-2003. Ban- galore: NCRP, ICMR; 2007. Available at: http://www.icmr.nic.in/ncrp/cancer_reg.html (last ac- cessed on August 5,.2013).
Parazzini F, Chatenoud L, Vecchia L C , Negri E, Fran- ceschi S, Bolis G. Determinants of risk of invasive cervi- cal cancer in young women. Br J Cancer.1998; 77:838- 41.
Vessey M, Painter R.Oral contraceptive use and cancer. Findings in a large cohort study, 1968–2004. Br J Cancer. 2006; 95: 385 –89.
Kogevinas M, Pearce N, Susser M, Boffetta P. Social inequalities and cancer. Lyon France: International Agency for Research on Cancer, World Health Organi- zation; 1997. Scientific Publication No.138. p 309-19.
Bull AR, Hatton P, Bensley DC, Bull SJ, Fryers PT. Standardized mortality from cervical cancer: a measure of performance. Journal of Public Health Medicine. 1994; 16:16-22.
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