A Case Control Study on Alcohol Consumption and Pancreatitis
DOI:
https://doi.org/10.55489/njcm.130620222076Keywords:
alcohol drinking, pancreatitis, case controlAbstract
Introduction: In Western population, a threshold of 5 drinks per day may exist for alcohol to increase pancreatitis risk. Given ethnic differences in alcohol metabolism, we examined the associations between smoking, alcohol, and pancreatitis in Western Indians.
Methods: A case control study was conducted in a surgery department of a hospital in western India. Information on drinking was collected by in-person interview. Baseline characteristics and alcohol consumption was compared between cases of pancreatitis and control (without pancreatitis).
Results: Baseline characteristics of cases and control are Among 4% of the cases and 2% of the control, bile stone was found to be present and this difference was also statistically not significant. Alcohol use was associated with pancreatitis in a dose-dependent way. Those who were taking heavy amount of alcohol had more than five and half-time risk of developing pancreatitis compared to those who are not taking alcohol.
Conclusions: Indians are more prone to alcohol-related pancreatitis than Westerners, and alcohol consumption is the leading cause of pancreatitis in India.
References
Whitcomb DC. Clinical practice. Acute pancreatitis. N Engl J Med. 2006; 354:2142-2150. Doi: https://doi.org/10.1056/NEJMcp054958 PMid:16707751
Forskmark CE. Chronic pancreatitis. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger & Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: WB Saunders; 2010:985-1015. Doi: https://doi.org/10.1016/B978-1-4160-6189-2.00059-7
Lankisch PG. Natural course of acute pancreatitis: what we know today and what we ought to know for tomorrow. Pancreas. 2009;38: 494-498. Doi: https://doi.org/10.1097/MPA.0b013e3181a11cb0 PMid:19550274
Takeyama Y. Long-term prognosis of acute pancreatitis in Japan. Clin Gastroenterol Hepatol. 2009;7:S15-S17. Doi: https://doi.org/10.1016/j.cgh.2009.08.022 PMid:19896091
Spanier BW, Dijkgraaf MG, Bruno MJ. Trends and forecasts of hospital admissions for acute and chronic pancreatitis in the Neth-erlands. Eur J Gastroenterol Hepatol. 2008;20:653-658. Doi: https://doi.org/10.1097/MEG.0b013e3282f52f83 PMid:18679068
Kristiansen L, Gronbaek M, Becker U, et al. Risk of pancreatitis according to alcohol drinking habits: a population-based cohort study. Am J Epidemiol. 2008;168:932-937. Doi: https://doi.org/10.1093/aje/kwn222 PMid:18779386
Yadav D, Hawes RH, Brand RE, et al. Alcohol consumption, cigarette smoking, and the risk of recurrent acute and chronic pancre-atitis. Arch Intern Med. 2009;169:1035-1045. Doi: https://doi.org/10.1001/archinternmed.2009.125 PMid:19506173 PMCid:PMC6785300
Brooks PJ, Enoch MA, Goldman D, et al. The alcohol flushing response: an unrecognized risk factor for esophageal cancer from al-cohol consumption. PLoS Med. 2009;6:e50. Available from: http://www.plosmedicine.org/ arti-cle/info%3Adoi%2F10.1371%2Fjournal.pmed.1000050. doi: https://doi.org/10.1371/journal.pmed.1000050 PMid:19320537 PMCid:PMC2659709
Chan AW. Racial differences in alcohol sensitivity. Alcohol Alcohol. 1986; 21:93-104.
Irving HM, Samokhvalov AV, Rehm J. Alcohol as a risk factor for pancreatitis. A systematic review and meta-analysis. JOP. 2009;10:387-392.
Lee CH, Lee JM, Wu DC, et al. Carcinogenetic impact of ADH1B and ALDH2 genes on squamous cell carcinoma risk of the esophagus with regard to the consumption of alcohol, tobacco and betel quid. Int J Cancer. 2008;122:1347-1356. Doi: https://doi.org/10.1002/ijc.23264 PMid:18033686
Apte MV, Wilson JS. Stellate cell activation in alcoholic pancreatitis. Pancreas. 2003;27:316-320. Doi: https://doi.org/10.1097/00006676-200311000-00008 PMid:14576494
Nordback IH, Olson JL, Chacko VP, et al. Detailed characterization of experimental acute alcoholic pancreatitis. Surgery. 1995;117:41-49. Doi: https://doi.org/10.1016/S0039-6060(05)80228-4
Chen YJ, Chen C, Wu DC, et al. Interactive effects of lifetime alcohol consumption and alcohol and aldehyde dehydrogenase poly-morphisms on esophageal cancer risks. Int J Cancer. 2006;119:2827-2831. Doi: https://doi.org/10.1002/ijc.22199 PMid:17036331
Gemma S, Vichi S, Testai E. Individual susceptibility and alcohol effects: biochemical and genetic aspects. Ann Ist Super Sanita. 2006;42:8-16.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Keyur Surati, Jainam Shah, Yogesh Modiya, Jatin Modi, Kushal Prajapati, Aneri Shah
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.