Comparison Of Intravitreal Triamcinolone Injection Vs Laser Photocoagulation in Angiographic Macular Edema in Diabetic Retinopathy

Authors

  • Somesh V Aggarwal M. & J Western Regional Institute of Ophthalmology, Civil Hospital campus, Ahmedabad
  • Sonali N Shah M. & J Western Regional Institute of Ophthalmology, Civil Hospital campus, Ahmedabad
  • Rekha M Bharwada M. & J Western Regional Institute of Ophthalmology, Civil Hospital campus, Ahmedabad
  • Puja S Negi M. & J Western Regional Institute of Ophthalmology, Civil Hospital campus, Ahmedabad
  • Nimesh M Jain M. & J Western Regional Institute of Ophthalmology, Civil Hospital campus, Ahmedabad

Keywords:

Diabetic Retinopathy, Macular edema, Laser Photocoagulation, Intravitreal injection

Abstract

Aims: To compare the effect of laser photocoagulation and intravitreal triamcinolone acetonide in the treatment of diabetic macular edema

Material and Methods: During the period of one year 100 patients having diabetic macular edema were enrolled in the project. Fluorescein angiography was carried out in all patients to confirm the diagnosis of macular edema Patients were randomly assigned into two groups. One group was treated with laser photocoagulation and other group was given intravitreal triamcinolone.

Observations: The patients registered in the project were in the age range of 40 to 76 years. The main outcome measures were visual acuity and macular edema on angiography. At three months patients receiving triamcinolone had better visual acuity compared to laser photocoagulation. However these findings were reversed by 12 months and laser photocoagulation remained superior to triamcinolone at the end of 1 year of follow up.

Discussion: A similar study conducted by DRCR compared laser photocoagulation to intravitreal triamcinolone for treatment of diabetic macular edema. At four months, patients receiving intravitreal triamcinolone had better visual acuity compared to laser photocoagulation. These findings were reversed by 16 months, and laser photocoagulation remained superior to triamcinolone at three-year follow-up.

Conclusion: To conclude our study showed that although intravitreal triamcinolone was successful in improving visual acuity in patients at the end of 3 months the effect was transient and in long term laser photocoagulation was more effective.

References

Early treatment of diabetic retinopathy study research group. Early photocoagulation for diabetic retinopathy. ETDRS report number 9.ophthalmology 1991,pg 19-21.

Desatnik H, Habot-Wilner Z, Alhalel A, Moroz I, Glovinsky J, Moisseiev J. The transient efficacy of a single intravitreal triamcinolone acetonide injection for diabetic macular edema. The retina journal 2006;8:383–7.

Massin P, Audren F, Haouchine B, et al. Intravitreal triamcinolone acetonide for diffuse diabetic macular edema – preliminary results of a prospective controlled trial. Ophthalmology 2004;111: 218–25

Jonas JB, Akkoyun I, Kreissig I, Degenring RF. Diffuse diabetic macular oedema treated by intravitreal triamcinolone acetonide: a comparative, non-randomised study. Br J Ophthalmol 2005;89:321–6.

Avitabile T, Longo A, Reibaldi A. Intravitreal triamcinolone compared with macular laser grid photocoagulation for the treatment of cystoid macular edema. Am J Ophthalmol 2005;140:695–702.

Patelli F, Fasolino G, Radice P, et al. Time course of changes in retinal thickness and visual acuity after intravitreal triamcinolone acetonide for diffuse diabetic macular edema with and without previous macular laser treatment. Retina 2005;25:840–5

Intravitreal triamcinolone versus laser photocoagulation for persistent diabetic macular oedema Z K Ockrim, S Sivaprasad, S Falk, S Roghani, C Bunce, Z Gregor, P Hykin Br J Ophthalmol 2008;92:795-79

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Published

2012-09-30

How to Cite

1.
Aggarwal SV, Shah SN, Bharwada RM, Negi PS, Jain NM. Comparison Of Intravitreal Triamcinolone Injection Vs Laser Photocoagulation in Angiographic Macular Edema in Diabetic Retinopathy. Natl J Community Med [Internet]. 2012 Sep. 30 [cited 2024 Apr. 22];3(03):437-41. Available from: https://njcmindia.com/index.php/file/article/view/1738

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Original Research Articles