Treatment Outcome of Tuberculosis in HIV Seropositive Patients: An Experience of Southeast Region of Ahmedabad
Keywords:
TB, HIV, DOTs, RNTCP, CD4Abstract
Objectives: To evaluate the clinical profile and the factors influencing treatment outcome of TB patients co-infected with HIV attending DOT centers of Southeast area of Ahmedabad, Gujarat
Methodology: A Prospective observation study was conducted to assess the treatment outcome of TB in TB-HIV co-infected patients on DOTs conducted at L.G. Hospital and tuberculosis units (TUs) of south and east region of Ahmedabad. TB patients started DOTS were registered and were followed till treatment outcome was declared.
Results: The treatment success rate was found to be 84.17% (101 of 120 patients). Treatment success rate of Tuberculosis among HIV se- ropositive patients was significantly associated with WHO clinical and Functional staging (p value <0.001), alcoholism (p value <0.001) and drug intolerance (p value <0.001).No significant association was found with concurrent Anti Retro Viral Therapy and socio economic classes.
Conclusion: The DOTS was found to be as effective in HIV seroposi- tive, so it should be strengthened, in order to control the HIV-TB epi- demic.
References
AIDS Control and Prevention (AIDSCAP) Project of Fam- ily Health Internal, The Francois-Xavier Bagnoud Center for Public Health and Human Rights Of the Harvard School of Public Health, UNAIDS. The Status and Trends of the Global HIV/AIDS Pandemic. Report July 5-6, 1996.
Reviglione MC, Snider DE, Kochi A. Global epidemiol- ogy of Tuberculosis, morbidity and mortality of world- wide epidemic, JAMA, 1995, 273, 220-226.
Reviglione MC, Narain P, Kochi A. HIV associated Tu- berculosis in developing countries: clinical features, di- agnosis and treatment WHO Bull 1992; 70; 516-526.
Training Module for Medical Officers on TB/HIV. Cen- tral TB Division & National AIDS Control Organization, New Delhi, August 2005; 1-3.
Training Manual for Medical officers on HIV-AIDS Cen- tral TB Division & National AIDS Control Organization, New Delhi, April 2002; 8-10.
World Health Organization. Antiretroviral therapy for HIV infection in adults and adolescents: recommenda- tions for a public health approach. Geneva: Switzerland: WHO, 2006. http://www.who.int/hiv/pub/guidelines/ artadultguidelines.pdf Accessed February 2008.
Tripathy S et al. Clinical response of newly diagnosed HIV seropositive & seronegative pulmonary tuberculosis patients with the RNTCP Short Course regimen in Pune, India. Indian J Med Res May 2011; 133:521-528
Vijay S, kumar P. et al 2011 “Treatment Outcome and Mortality at One and Half Year Follow-Up of HIV In- fected TB Patients under TB Control Programme in a Dis- trict of South India” [Internet] http://www.plosone.org
/article/info
Shetty N et al. An epidemiological evaluation of risk factors for tuberculosis in South India. Int J of TB & Lung Dis 2006; 10(1):80–86
Ahemad Z, Mohd Shameem. Manifestations of Tubercu- losis in HIV Infected Patients. JIACM 2005; 6(4): 302-5.
Kuma P, Niraj Sharma et al. Clinical Profile of Tuberculo- sis in Patients with HIV Infection/AIDS. Rajan Babu T.B. Hospital and Infectious Diseases Hospital, G.T.B. Nagar, Delhi. Indian J Chest Dis Allied Sci 2002; 44 : 159 – 163.
Gupta P et al. HIV sero-prevalence and tuberculosis in Uttaranchal. Indian J Tuberc 2006; 53:96-100.
Patel et al. Clinical and laboratory profile of patients with TB/HIV coinfection: A case series of 50 patients. Lung India 2011; 28(2):93-6
Rajasekaran et al. Manifestation of tuberculosis in pa- tients with human immunodeficiency virus: A large In- dian Study. Annals of Thoracic edicine-2007; 2 (2): 58-60
Gill N et al. Treatment Outcome of Tuberculosis in Sero- positive Patients in a Tertiary Care Hospital and ART Centre in Mumbai, India. Int J Med Health Sci. 2013;2(3): 322-330.
Chennaveerappa PK et al. Treatment outcome of tubercu- losis patients registered at dots centre in a teaching hospi- tal, south India. Int J Biol Med Res. 2011; 2(2): 487-489
S.Chideya et al. Isoniazid, Rifampin, Ethambutol, and Pyrazinamide Pharmacokinetics and Treatment Out- comes among a Predominantly HIV-Infected Cohort of Adults with Tuberculosis from Botswana. Clin Infect Dis 2009; 48 (12): 1685-1694
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.
