Safety And Effectiveness of Intravenous Iron Sucrose Versus Oral Iron: A Study Among Preoperative Anemic Women with Menorrhagia
Keywords:
Preoperative anemia, oral iron, parenteral iron, iron sucroseAbstract
Objective: To compare the safety and efficacy of iron sucrose over oral iron for the correction of preoperative anemia in women with menorrhagia.
Methods: Women with menorrhagia having Hemoglobin (Hb) <10 gm/dl and features of iron deficiency allocated to group A (IV iron sucrose) or group B (oral iron). IV iron sucrose was administered as 100 mg (2 ampoules) in 100 ml normal saline by slow IV infusion. The women in the group B received ferrous sulphate as oral iron in the dose of one tablet (200 mg salt) three times a day. Repeat laboratory estimations were done after four weeks.
Results: Before treatment, mean Hemoglobin level (mean ± SD) was similar in both groups (7.18 ± 1.18 gm/dl in group A and 7.18 ± 1.02 gm/dl in group B). After treatment, rise of Hb level was more in group A (10.70 ± 0.73 gm/dl) than group B (9.64 ± 0.70 gm/dl). After treatment, the desired Hb level of 10 gm/dl or more were achieved in 96% of women in group A while only in 56% of women in group B.
Conclusion: Preoperative intravenous iron sucrose administration is more effective than oral iron and is as safe as oral iron therapy in the correction of preoperative anemia due to menorrhagia.
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