Prevalence of Perceived Stress Among Polypharmacy Patients: A Cross-sectional Study
DOI:
https://doi.org/10.55489/njcm.151220244677Keywords:
PSS-10, Polypharmacy, Perceived stress, Adverse effects, AdherenceAbstract
Background: The concurrent use of 5 or more medications is the most recognized definition of polypharmacy. Many physical and mental consequences could be associated with polypharmacy, and stress is no exception. The objective of the current study is to investigate the prevalence of perceived stress among polypharmacy individuals and its association with sociodemographic factors.
Method: A cross-sectional study was carried out between September and December at 6 major hospitals and several private clinics in Iraq. Study participants were required to have at least 2 chronic diseases and be using 5 or more drugs for at least 90 days, aged 50 years or older. Sociodemographic data and the Perceived Stress Scale 10 (PSS-10) were completed by participants. The Mann-Whitney test was used to compare the median PSS-10 scores for different sociodemographic factors.
Results: Among the 235 polypharmacy participants, the median PSS-10 score was 20. Moreover, the median PSS-10 score was significantly higher among female participants, those with an increased number of chronic diseases, the presence of adverse effects, and participants with financial issues related to healthcare (P <0.05).
Conclusion: The present findings indicate a moderate perceived stress score among polypharmacy participants, highlighting the need for strategies to alleviate stress alongside personalized medication management.
References
Pazan F, Wehling M. Polypharmacy in older adults: a narrative review of definitions, epidemiology and consequences. Eur Geriatr Med. 2021;12(3):443-452. DOI: https://doi.org/10.1007/s41999-021-00479-3 PMid:33694123 PMCid:PMC8149355
Delara M, Murray L, Jafari B, et al. Prevalence and factors associated with polypharmacy: a systematic review and Meta-analysis. BMC Geriatr. 2022;22(1):601. DOI: https://doi.org/10.1186/s12877-022-03279-x PMid:35854209 PMCid:PMC9297624
Mortazavi SS, Shati M, Keshtkar A, Malakouti SK, Bazargan M, Assari S. Defining polypharmacy in the elderly: a systematic review protocol. BMJ Open. 2016;6(3):e010989. DOI: https://doi.org/10.1136/bmjopen-2015-010989 PMid:27013600 PMCid:PMC4809106
Montiel-Luque A, Núñez-Montenegro AJ, Martín-Aurioles E, Canca-Sánchez JC, Toro-Toro MC, González-Correa JA. Medication-related factors associated with health-related quality of life in patients older than 65 years with polypharmacy. PLoS ONE. 2017;12(2):e0171320. DOI: https://doi.org/10.1371/journal.pone.0171320 PMid:28166266 PMCid:PMC5293190
Alhashem G, Alyasery R, Al-Hassan S. The association between depressive symptoms and medication adherence among polypharmacy older adults. Eur Psychiatry. 2024;67(S1):S363-S363. DOI: https://doi.org/10.1192/j.eurpsy.2024.748
Assari S, Bazargan M. Polypharmacy and Psychological Distress May Be Associated in African American Adults. Pharmacy. 2019;7(1):14. DOI: https://doi.org/10.3390/pharmacy7010014 PMid:30682807 PMCid:PMC6473809
Van Wilder L, Devleesschauwer B, Clays E, Pype P, Vandepitte S, De Smedt D. Polypharmacy and Health-Related Quality of Life/Psychological Distress Among Patients With Chronic Disease. Prev Chronic Dis. 2022;19:E50. DOI: https://doi.org/10.5888/pcd19.220062 PMid:35980834 PMCid:PMC9390791
Chaaya M, Osman H, Naassan G, Mahfoud Z. Validation of the Arabic version of the Cohen perceived stress scale (PSS-10) among pregnant and postpartum women. BMC Psychiatry. 2010;10(1):111. DOI: https://doi.org/10.1186/1471-244X-10-111 PMid:21159169 PMCid:PMC3016315
Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. Published online 1983:385-396. DOI: https://doi.org/10.2307/2136404 PMid:6668417
Choi J. Impact of Stress Levels on Eating Behaviors among College Students. Nutrients. 2020;12(5):1241. DOI: https://doi.org/10.3390/nu12051241 PMid:32349338 PMCid:PMC7284653
Graves BS, Hall ME, Dias-Karch C, Haischer MH, Apter C. Gender differences in perceived stress and coping among college students. PLoS ONE. 2021;16(8):e0255634. DOI: https://doi.org/10.1371/journal.pone.0255634 PMid:34383790 PMCid:PMC8360537
Taylor JM. Psychometric analysis of the Ten-Item Perceived Stress Scale. Psychol Assess. 2015;27(1):90-101. DOI: https://doi.org/10.1037/a0038100 PMid:25346996
Vancampfort D, Koyanagi A, Ward PB, et al. Perceived Stress and Its Relationship With Chronic Medical Conditions and Multimorbidity Among 229,293 Community-Dwelling Adults in 44 Low- and Middle-Income Countries. Am J Epidemiol. 2017;186(8):979-989. DOI: https://doi.org/10.1093/aje/kwx159 PMid:28637230
Khezrian M, McNeil CJ, Myint PK, Murray AD. The association between polypharmacy and late life deficits in cognitive, physical and emotional capability: a cohort study. Int J Clin Pharm. 2019;41(1):251-257. DOI: https://doi.org/10.1007/s11096-018-0761-2 PMid:30499028 PMCid:PMC6394523
Wu Y, Levis B, Riehm KE, et al. Equivalency of the diagnostic accuracy of the PHQ-8 and PHQ-9: a systematic review and individual participant data meta-analysis. Psychol Med. 2020;50(8):1368-1380. DOI: https://doi.org/10.1017/S0033291719001314 PMid:31298180 PMCid:PMC6954991
Adams DR, Meyers SA, Beidas RS. The relationship between financial strain, perceived stress, psychological symptoms, and academic and social integration in undergraduate students. J Am Coll Health. 2016;64(5):362-370. DOI: https://doi.org/10.1080/07448481.2016.1154559 PMid:26943354 PMCid:PMC5086162
Yoshida Y, Ishizaki T, Masui Y, et al. Association of personality traits with polypharmacy among community-dwelling older adults in Japan: a cross-sectional analysis of data from the SONIC study. BMC Geriatr. 2022;22(1):372. DOI: https://doi.org/10.1186/s12877-022-03069-5 PMid:35484487 PMCid:PMC9047377
Bazargan M, Smith J, Saqib M, Helmi H, Assari S. Associations between Polypharmacy, Self-Rated Health, and Depression in African American Older Adults; Mediators and Moderators. Int J Environ Res Public Health. 2019;16(9):1574. DOI: https://doi.org/10.3390/ijerph16091574 PMid:31064059 PMCid:PMC6539372
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ghazwan Alhashem
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
The authors retain the copyright of their article, with first publication rights granted to Medsci Publications.