Study of Socio Demographic Predictors of Adherence of Anti Retroviral Therapy (ART) among HIV Positive Patients – A Case Control Study

Authors

  • Bhautik P Modi GMERS Medical College, Gandhinagar, Gujarat
  • Vaibhav Gharat GMERS Medical College, Valsad, Gujarat
  • Prakash B Patel SMIMER, Surat
  • Sunil Nayak GMERS Medical College, Valsad, Gujarat
  • Rachna Prasad SMIMER, Surat
  • R K Bansal SMIMER, Surat

Keywords:

HIV, AIDS, Ante retroviral Therapy, ART, Pill count

Abstract

Introduction: After starting free Anti Retroviral Therapy (ART) in India, challenge has changed from gaining access to taking the treatment correctly and consistently in order to realize the rewards of improved health status, and reduced morbidity and mortality from HIV. This study was aimed to identify of socio-demographic risk factors responsible for non-adherence to ART.

Methodology: This Case Control Study was conducted at ART centre where all patients with poor adherence percentage i.e. ≤ 95% of Treatment Adherence were denoted as ‘Case’ and good adherence percentage i.e. > 95% of Treatment Adherence were denoted as ‘Control’. The ‘Pill Count method’ was used to measure the adherence level.

Results: Mean age of 104 cases and 208 unmatched controls was 36.29 years and 39.21 years respectively (p <0.05). Females were more common among cases than controls. Total 15.4% of cases and 7.7% of controls were from the rural area (OR: 2.18 (1.04 - 4.56) and p-Value < 0.05). Post-test counselling was not done in 10% of cases and 4% of controls. [OR: 2.66 (1.02 - 6.96)& p-Value < 0.05].

Conclusion: Poor adherence was more in younger, female, rural residence, low family income, disclosure of HIV positive status and patients undergone post test counselling.

References

Simoes, E.A. Evidence for HTLV-III infection in prostitutes in Tamil Nadu (India). Indian Journal of Medical Re-search;85:335-8.

National AIDS Control Organization (2012). Department of AIDS Control, Ministry of Health and Family Welfare, Gov-ernment of India, Annual Report 2011-2012.

Golin CE, Liu H, Hays RD, Miller LG, Beck CK, Ickovics J, Kaplan AH, Wenger NS. A prospective study of predictors of adherence to combination antiretroviral medication. J Gen Intern Med 2002; 17:756-65.

Paterson DL, Swindells S, Mohr J, Brester M, Vergis EN, Squier C, Wagener MM, Singh N. Adherence to protease in-hibitor therapy and outcomes in patients with HIV infec-tion. Ann Intern Med 2000; 133:21-30.

Gifford AL, Bormann JE, Shively MJ, Wright BC, Richman DD, Bozzette SA. Predictors of self-reported adherence and plasma HIV concentrations in patients on multidrug an-tiretroviral regimens. J Acquir Immune DeficSyndr 2000; 23:386-95.

KidangazhiathmanaAjithkumar, PoovasseryGovindhan-Neera, ParasseryParameswaranRajani. Relationship be-tween social factors and treatment adherence: a study from south India. Eastern Journal of Medicine 2011; 16:147-52

Mannheimer S, Friedland G, Matts J, Child C, Chesney M. The consistency of adherence to antiretroviral therapy pre-dicts biologic outcomes for human immunodeficiency vi-rus-infected persons in clinical trials. Clin Infect Dis 2002; 34:1115-21.

UNGASS (2010). Country progress report, UNGASS, India. March 31, 2010.

GSNP+, GSACS, UNDP.A Needs Assessment study: People living with HIV/AIDS In Gujarat 2006.

Wasti SP, Simkhada P, Randall J, Freeman JV, van Teijlingen E (2012) Factors Influencing Adherence to An-tiretroviral Treatment in Nepal: A MixedMethods Study. PLoS ONE 7(5): e35547.

Miller LG, Liu H, Hays RD, Golin CE, Ye Z, Beck CK, Kaplan AH, Wenger NS. Knowledge of antiretroviral regi-men dosing and adherence: a longitudinal study. Clin Infect Dis 2003; 36:514-8.

Gordillo V, delAmo J, Soriano V, Gonzalez-Lahoz J (1999). Sociodemographic and psychological variables influencing adherence to antiretroviral therapy 1999. AIDS; 13:1763-9.

Fogarty L, Roter D, Larson S, Burke J, Gillespie J, Levy R. Patient adherence to HIV medication regimens: a review of published and abstract reports. Patient EducCouns 2002; 46:93-108.

Kleeberger CA, Phair JP, Strathdee SA, Detels R, Kingsley L, Jacobson LP. Determinants of heterogeneous adherence to HIV-antiretroviral therapies in the Multicenter AIDS Cohort Study. J Acquir Immune DeficSyndr 2001; 26:82-92.

Rintamaki, LS. Davis, TC. Skripkauskas. S. Bennett, CL and Wolf, MS. Social stigma concerns and HIV medication adherence. AIDS patient care and STD 2006. 20(5):359-396.

Downloads

Published

2017-12-31

How to Cite

1.
Modi BP, Gharat V, Patel PB, Nayak S, Prasad R, Bansal RK. Study of Socio Demographic Predictors of Adherence of Anti Retroviral Therapy (ART) among HIV Positive Patients – A Case Control Study. Natl J Community Med [Internet]. 2017 Dec. 31 [cited 2024 Nov. 21];8(12):750-4. Available from: https://njcmindia.com/index.php/file/article/view/1826

Issue

Section

Original Research Articles