Case Fatality Rate among Septicemia Patients in a Tertiary Care Hospital of Western India

Authors

  • Kamalchandra P Naik SMIMER, Surat
  • Dipika Patel SMIMER, Surat
  • Bhautik N Patel SMIMER, Surat
  • Dharmil M Patel SMIMER, Surat

Keywords:

Sepsis, fataity rate, Gram stain, Septicemia, Gram positive, Gram negative

Abstract

Objective: The present study was carried out to study common sites of infection and organisms leading to sepsis commonly, to study various agents and host factors leading to sepsis and their prognostic importance and fatality rate due to sepsis.

Method: The present prospective study was conducted in patients with clinical features suggestive of sepsis were included in the study. Gram stain and culture of the material from the primary site of infection for the microbial etiology was taken. Other appropriate laboratory data depending upon the requirement was done.

Results: Among 50 cases of sepsis studied, 34 were male (68%) and 16 were female (32%). DM was the common co-morbid condition along with IHD, COPD, pulmonary Koch’s, hypertension and alcoholic liver disease. The common complications were respiratory failure, kidney failure and shock. The overall case fatality rate was found to be 42%.It was observed that mortality was higher among the patients presenting with shock (73%) and abnormal liver function tests (70%).

Conclusion: Higher fatality rate was associated with age above 58 years, female gender, increase in co-morbid conditions, patients presenting with shock and abnormal liver function tests and increase in number of organ failures. Mortality was higher in patients with positive blood culture and patients with gram negative septicemia.

References

Das UN. Recent advances in the pathobiology of septicemia and septic shock.JAPI, 2000: 148, 1181-84

Calandra T, Cohen J. The international sepsis forum consen-sus conference on definitions of infection in the intensive care unit. Critical care medicine. 2005 Jul 1;33(7):1538-48.

Martin GS, Mannino DM, Eaton S, Moss M. The epidemiol-ogy of sepsis in the United States from 1979 through 2000. New England Journal of Medicine. 2003 Apr 17;348(16):1546-54.

Rubenfeld GD, Angus DC, Pinsky MR, Curtis JR, Connors AF Jr, Bernard GR. Outcomes research in critical care: re-sults of the American Thoracic Society Critical Care Assem-blyWorkshop on Outcomes Research. Am J RespirCrit Care Med 1999;160:358-367.

Wenzel RP, Edmond MB. Managing antibiotic resistance. N Engl J Med 2000;343:1961-1963.

Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. 2001 sccm/esicm/accp/ats/sis international sepsis definitions conference. Intensive care medicine. 2003 Apr 1;29(4):530-8.

Muckart DJ, Bhagwanjee S. American College of Chest Phy-sicians/Society of Critical Care Medicine Consensus Con-ference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically in-jured patients. Critical care medicine. 1997 Nov 1;25(11):1789-95.

Vincent JL, Sakr Y, Sprung CL, Ranieri VM, Reinhart K, Ger-lach H, Moreno R, Carlet J, Le Gall JR, Payen D, Sepsis Oc-currence in Acutely Ill Patients Investigators. Sepsis in Eu-ropean intensive care units: results of the SOAP study. Crit-ical care medicine. 2006 Feb 1;34(2):344-53.

Chatterjee S, Todi S, Sahu S, Bhattacharyya M. Epidemiolo-gy of severe sepsis in India. Critical Care. 2009 Mar 13;13(1):P345.

Oliveira AP, Barata CH, Murta EF, Tavares-Murta BM. Comparative study of survivor and nonsurvivor sepsis pa-tients in a university hospital. Revista da SociedadeBrasilei-ra de Medicina Tropical. 2008 Feb;41(1):50-4.

Sreedharan S, Faizal B, Manohar R, Pillai MG. Patterns and complications of sepsis in critically ill patients and the role of APACHE IV score in predicting mortality. Amrita Journal of Medicine. 2012 Jan;8(1):19-23.

Silva E, de Almeida Pedro M, Sogayar AC, Mohovic T, Silva CL, Janiszewski M, Cal RG, de Sousa ÉF, Abe TP, de An-drade J, de Matos JD. Brazilian sepsis epidemiological study (BASES study). Critical Care. 2004 Jun 15;8(4):R251.

Blanco J, Muriel-Bombín A, Sagredo V, Taboada F, Gandía F, Tamayo L, Collado J, García-Labattut Á, Carriedo D, Valledor M, De Frutos M. Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Critical Care. 2008 Dec 17;12(6):R158.

Goldwasser R, David C, Hatum R, Salles J, Barbosa O, Piras C, Braga M, Macedo G, Fundo G. Microbiology profile of sepsis in Brazil. Critical Care. 2007 Mar 22;11(2):P67.

Angus DC, Linde-Zwirble WT, Lidicker J, et al.: Epidemiol-ogy of severe sepsis in the United States: analysis of inci-dence,outcome and associated costs of care. Crit Care Med 2001, 29:1303-1310

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Published

2017-11-30

How to Cite

1.
Naik KP, Patel D, Patel BN, Patel DM. Case Fatality Rate among Septicemia Patients in a Tertiary Care Hospital of Western India. Natl J Community Med [Internet]. 2017 Nov. 30 [cited 2024 Apr. 20];8(11):694-7. Available from: https://njcmindia.com/index.php/file/article/view/1651

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Original Research Articles