Future of TB Prevention: An Alternative To BCG


  • Sneka P Bhaarath Medical College and Hospital, Biher, Chennai, India
  • Sangamithrav V Bhaarath Medical College and Hospital, Biher, Chennai, India
  • Hamsadwani KP Bhaarath Medical College and Hospital, Biher, Chennai, India




Bacille Calmette Guerin (BCG), novel TB vaccines, phases of clinical trials, challenges


Mycobacterium tuberculosis is a killer bacteria endangering the life of many innocent people worldwide. There is an emergency need for newer TB vaccines to combat this deadly disease. The BCG vaccine currently being delivered has been in use for more than a decade but still the threat has been increasing day-by-day worldwide and more particularly among the developing nations. It is necessary to develop a candidate vaccines which can keep a check on the  primary progression of the disease and also reactivation of Latent TB Infection.


Hatherill M, White RG, Hawn TR. Clinical development of new TB vaccines: recent advances and next steps. Frontiers in microbiolo-gy. 2020 Jan 30;10:3154. Doi: https://doi.org/10.3389/fmicb.2019.03154 PMid:32082273 PMCid:PMC7002896

Sean Saramagoet al.,Tuberculosis Vaccines: An Update of Recent and Ongoing Clinical Trials , Appl. Sci. 2021, 11, 9250. Doi: https://doi.org/10.3390/app11199250

Thomas J. Scriba et al.,Key recent advances in TB vaccine development and understanding of protective immune responses against Mycobacterium tuberculosis , Seminars in Immunology 50 (2020) 101431. Doi: https://doi.org/10.1016/j.smim.2020.101431 PMid:33279383 PMCid:PMC7786643

Priya Venkatesan,Progress in tuberculosis vaccine research www.thelancet.com/microbe Vol 2 January 2021 e12. Doi: https://doi.org/10.1016/S2666-5247(20)30228-7

Stefan H.E.Kaufmann et al.,vaccine development against TB over the last 140 years : Failure as part of success/Frontiers in Microbi-ology/oct 2021/vol 12/article 750124. Doi: https://doi.org/10.3389/fmicb.2021.750124 PMid:34691001 PMCid:PMC8526900

Suraj B.Sable, James,Thomas J.Scriba et al; Tuberculosis Vaccine Development: Progress in Clinical Evaluation/cmr/jan 2020 /vol 33 issue 1 e00100-19. Doi: https://doi.org/10.1128/CMR.00100-19 PMid:31666281 PMCid:PMC6822991

C.K.Weersuriya, R.A.Clark, R.G.White et al.,New Tuberculosis Vaccines:advances in clinical development and modelling.,Journal of Internal Medicine, 2020, 288;661-681. Doi: https://doi.org/10.1111/joim.13197 PMid:33128834




How to Cite

P S, V S, KP H. Future of TB Prevention: An Alternative To BCG. Natl J Community Med [Internet]. 2022 Oct. 31 [cited 2022 Dec. 9];13(10):758-9. Available from: https://njcmindia.com/index.php/file/article/view/2404



Letter to Editor