Comparison Of Injection Vitamin B12 With Symptomatic Management in Clinically Suspected Vitamin B12 Deficient Patients: An Interventional Study

Authors

  • Janak Rathod SMIMER, Surat
  • Taral Shah SMIMER, Surat
  • Manisha Gupta Santosh Medical College, Ghaziabad
  • Rajendra Mehta SMIMER, Surat

Keywords:

Injection Vit. B 12, Symptomatic management

Abstract

Objectives: This study was an attempt to evaluate the advantage of empirical use of Injection. Vitamin B 12 versus symptomatic management in clinically suspected Vitamin. B 12 deficient patients.

Methodology: A total of 100 patients over 20 years of age (irrespective of gender) were included in the study. The patients were divided into two groups, one group ( n = 50) receiving vitamin B12 injections and the other group (n = 50) received symptomatic treatment.

Results: In clinically suspected vitamin B12 deficient patients after giving empirical therapy of Inj. Vit B 12; generalized fatigue (96%), pareshtesia (93.48%), myalgia (93.75%), loss of appetite (88.89%), confusion (93.75%) and tremor (93.55%) were improved with ( p<0.001). Labored breathing and depression were also improved with Inj.Vit B 12 as compared to symptomatic management, but this difference was statistically insignificant(p = 0.052 and p = 0.201 respectively).

Conclusion: We conclude and recommend from the study to treat clinically suspected Vit. B 12 deficient patients with empirical Vit. B 12 Injections without the need of costly serum Vit. B 12 estimation.

References

Harper textbook of biochemistry (27th edition)

K Park. Park’s Textbook of Preventive and Social Medicine, 21st ed. Jabalpur: Bhanot Publishers; 2011. p 573.

3.Misra UK, Kalita J, Das A. Vitamin B12 deficiency neurological syndromes: A clinical, MRI and electrodiagnostic study. ElectromyogrClinNeurophysiol, 43:57-64, (2003).

Pandey S, Kalita J, Misra UK. A sequential study of visual evoked potential in patients with vitamin B12 deficiency neurological syndrome. ClinNeurophysiol, 115:914-918, (2004).

Refsum H, Yajnik CS, Gadkari M. HyperhomoCysteinemia and elevated methylmelonicindicate a high prevalence of cobalamine in Asian Indians. Am J ClinNutr 2001;74:233-41Institute of Medicine. Food and Nutrition Board. Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academy Press, 1998

Clarke R. B-vitamins and prevention of dementia. ProcNutrSoc 2008;67:75-81.

Carmel R. How I Treat Vit. B12 Deficiency. Blood.2008;112:2214-21 (PubMed Abstract)

Essentials of Medical Pharmacology. 6th Edition.(K.D.T)

http://www.buzzle.com/articles/vitamin-b12-overdose.html and http://www.buzzle.com/articles/vitamin-b12-injections-dosage.html(Accessed in October 2012) http://www.healthaliciousness.com/articles/Top-5-Natural-Vegetarian-sources- Vitamin- B12.php (Accessed in October 2012)

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Published

2012-12-31

How to Cite

1.
Rathod J, Shah T, Gupta M, Mehta R. Comparison Of Injection Vitamin B12 With Symptomatic Management in Clinically Suspected Vitamin B12 Deficient Patients: An Interventional Study. Natl J Community Med [Internet]. 2012 Dec. 31 [cited 2024 Nov. 23];3(04):728-31. Available from: https://njcmindia.com/index.php/file/article/view/1805

Issue

Vol. 3 No. 04 (2012)

Section

Original Research Articles

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