Mantle Cell Lymphoma of GI Tract Presented as Multiple Lymphomatous Polyposis: A Rare Intestinal Malignancy

Authors

  • Kirti M Rathod PSMC, Karamsad
  • Monica V Gupta PSMC, Karamsad
  • Kalpesh H Shah PSMC, Karamsad
  • Keyuri B Patel PSMC, Karamsad

Keywords:

Mantle cell, lymphoma, polyposis, malignancy, GI track

Abstract

Primary lymphomas arising in the large intestine are less frequent than either gastric or small bowel lymphomas. Primary colorectal lymphomas account for about 0.2% of all neoplasm. Mantle cell lymphoma in form of multiple lymphomatous polyposis is less frequent in colorectum than in the small bowel.2 We present a case of 68 year-old man suffered from abdominal pain and diarrhoea for one year with complain of blood in stool for last 15 days. Multiple polypoid masses were found in the entire colon and caecum on colonoscopic examination. Computerized tomography of the abdomen revealed a large soft tissue mass lesion in caecum and ascending colon with diffuse polypoidal wall thickening involving the transverse colon, sigmoid colon, descending colon with mesenteric lymph node enlargement. Colonoscopic excision of polyp from ascending colon and transverse colon was done. The histological diagnosis was Non-Hodgkin lymphoma with multiple lymphomatous polyposis. In immunohitochemistry, there was positive staining for CD20, CD 5 and cyclin D1 and suggestive of mantle cell lymphoma B cell type. MCL is an aggressive lymphoma, which typically presents in advanced stage; there is often involvement of mesenteric and peripheral lymph nodes, spleen, bone marrow and peripheral blood 6.

References

Stacey E Millis, Darryl Carter, Joel K Greenson, Harold A Oberman. Sternberg’ Diagnostic Surgical Pathology, 4th edition, 2004, 1582-1587.

Shephered NA, Hall PA, Coates P J, Levison DA. Primary malignant lymphoma of the colon and rectum. A histopathological and immunohistochemical analysis of 45 cases with clinopathological correlations. Histopathology, 1988; 12: 235-252.

Weisenburger DD, Armitage JO. Mantle cell lymphoma- an entity comes of age Blood, 1996; 87: 4483-4494.

Isaacson P , MacLennan KA, Subbuuswamy SG. Multiple lymphomatous polyposis of the gastrointestinsal tract. Histopathology, 1984; 8: 641-656.

Banks PM, Chan J, Cleary ML,Delsol G, De-wolf-Peeters C,Gatter K, Grogan TM,Harris NL, Isaacson PG, Jaffe ES, et al. Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular data. Am J Surg Pathol, 1992; 16: 637-640.

Harris NL, Jaffe ES, Stein H, Banks PM, Chan JK, Cleary ML, Delsol G, De Wolf-Peeters C, Falini B, Gatter KC. A revised European-American classification of lymphoid neoplasms: a proposal from the International Lymphoma Study Group. Blood, 1994; 84: 1361-1392.

Downloads

Published

2012-06-30

How to Cite

1.
Rathod KM, Gupta MV, Shah KH, Patel KB. Mantle Cell Lymphoma of GI Tract Presented as Multiple Lymphomatous Polyposis: A Rare Intestinal Malignancy. Natl J Community Med [Internet]. 2012 Jun. 30 [cited 2024 Mar. 29];3(02):357-9. Available from: https://njcmindia.com/index.php/file/article/view/1717

Issue

Section

Case Report