TY - JOUR AU - Kataria, Neetu AU - Kalyani, Vasantha C AU - Mirza, Anissa Atif AU - S, Vivekanandhan AU - Kumar, Mritunjai AU - Bharupi, Yogesh AU - Ranjan, Shashi AU - Kumar, Nitesh AU - Kumar, Niraj PY - 2022/10/31 Y2 - 2024/03/28 TI - Association Of the Methylene Tetrahydrofolate Reductase (MTHFR) Gene Polymorphism with Susceptibility to Recurrence of Cardiovascular Outcomes Among Ischemic Stroke- A Randomized Controlled Trial JF - National Journal of Community Medicine JA - Natl J Community Med VL - 13 IS - 10 SE - Original Research Articles DO - 10.55489/njcm.131020222420 UR - https://njcmindia.com/index.php/file/article/view/2420 SP - 692-697 AB - <p>Background: Hyperhomocystenemia and genetic variants are factors for causing young age stroke globally. This study aims to identify homocysteine related-MTHFR gene polymorphism that associated with recur-rent cardiovascular outcomes.</p><p>Methodology: A randomized controlled trial conducted upon 90 hyperhomocysteinemic ischemic stroke patients were taken from the neurology wards of a tertiary care hospital were randomly selected into vita-min B therapy group and control groups (n=45 in each group). Baseline subject details were collected ve-nous blood sample for MTHFR genetic testing via PCR-RFLP technique along with blood homocysteine lev-els, vitamin B12, folic acid levels.</p><p>Results: The results showed that the frequency of CT genotype polymorphism was 15.5% vs 13.3% for the MTHFR C677T gene without any significant difference between vitamin group and control group respective-ly (p-value &gt;0.05). The reduction in mean homocysteine up to -6.77±4.50 versus -2.08±0.71 µmol/L in the vitamin group as compared to control group respectively, p value 0.001.</p><p>Conclusion: Considerable amount of MTHFR gene polymorphism found among hyperhomocysteinemic is-chemic stroke of sub-Himalayan region. Nutritional deficiencies including vitamin B 12 &amp; folic acid, and some hidden reasons found, which could lead to the primary cause of hyperhomocysteinemia. Vitamin B therapy is an effective for reducing homocysteine.</p> ER -